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Inflammation, insulin resistance and neuroprogression in depression

Acta neuropsychiatrica, 2020-02, Vol.32 (1), p.1-9 [Peer Reviewed Journal]

Scandinavian College of Neuropsychopharmacology 2019. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0924-2708 ;EISSN: 1601-5215 ;DOI: 10.1017/neu.2019.17 ;PMID: 31186075

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  • Title:
    Inflammation, insulin resistance and neuroprogression in depression
  • Author: Leonard, Brian E ; Wegener, Gregers
  • Subjects: Alzheimer's disease ; Body fat ; Circadian rhythm ; Cytokines ; Dementia ; Diabetes ; Drugs ; Energy ; Glucose ; Inflammation ; Insulin resistance ; Longitudinal studies ; Mental depression ; Mental disorders ; Mental health ; Metabolic syndrome ; Metabolites ; Neurodegeneration ; Pathophysiology ; Psychotropic drugs
  • Is Part Of: Acta neuropsychiatrica, 2020-02, Vol.32 (1), p.1-9
  • Description: Chronic low-grade inflammation has been observed in major depression and other major psychiatric disorders and has been implicated in metabolic changes that are commonly associated with these disorders. This raises the possibility that the effects of dysfunctional metabolism may facilitate changes in neuronal structure and function which contribute to neuroprogression. Such changes may have implications for the progress from major depression to dementia in the elderly patient. The purpose of this review is to examine the contribution of inflammation and hypercortisolaemia, which are frequently associated with major depression, to neurodegeneration and how they detrimentally impact on brain energy metabolism. A key factor in these adverse events is insulin insensitivity caused by pro-inflammatory cytokines in association with desensitised glucocorticoid receptors. Identifying the possible metabolic changes initiated by inflammation opens new targets to ameliorate the adverse metabolic changes. This has resulted in the identification of dietary and drug targets which are of interest in the development of a new generation of psychotropic drugs.
  • Publisher: England: Cambridge University Press
  • Language: English;Dutch
  • Identifier: ISSN: 0924-2708
    EISSN: 1601-5215
    DOI: 10.1017/neu.2019.17
    PMID: 31186075
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
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