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Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study

BMJ open, 2014-01, Vol.4 (7), p.e005245-e005245 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2014 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/3.0/ Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2014 ;ISSN: 2044-6055 ;EISSN: 2044-6055 ;DOI: 10.1136/bmjopen-2014-005245 ;PMID: 24993766

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Title:
Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study
Author: Ferrari, Pietro ; Licaj, Idlir ; Muller, David C ; Kragh Andersen, Per ; Johansson, Mattias ; Boeing, Heiner ; Weiderpass, Elisabete ; Dossus, Laure ; Dartois, Laureen ; Fagherazzi, Guy ; Bradbury, Kathryn E ; Khaw, Kay-Tee ; Wareham, Nick ; Duell, Eric J ; Barricarte, Aurelio ; Molina-Montes, Esther ; Sanchez, Carmen Navarro ; Arriola, Larraitz ; Wallström, Peter ; Tjønneland, Anne ; Olsen, Anja ; Trichopoulou, Antonia ; Benetou, Vasiliki ; Trichopoulos, Dimitrios ; Tumino, Rosario ; Agnoli, Claudia ; Sacerdote, Carlotta ; Palli, Domenico ; Li, Kuanrong ; Kaaks, Rudolf ; Peeters, Petra ; Beulens, Joline WJ ; Nunes, Luciana ; Gunter, Marc ; Norat, Teresa ; Overvad, Kim ; Brennan, Paul ; Riboli, Elio ; Romieu, Isabelle
Subjects: Adult ; Aged ; Alcohol Drinking - adverse effects ; Alcohol use ; Breast cancer ; Cardiovascular disease ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cause of Death ; Community medicine, Social medicine: 801 ; Epidemiology ; Europe ; Exocrine glands ; Female ; Health Sciences ; Health sciences: 800 ; Health service and health administration research: 806 ; Heart ; Helsefag: 800 ; Helsetjeneste- og helseadministrasjonsforskning: 806 ; Humans ; Hälsovetenskap ; Injuries ; Larynx ; Lifestyles ; Male ; Medical and Health Sciences ; Medical disciplines: 700 ; Medical research ; Medical screening ; Medicin och hälsovetenskap ; Medisinske Fag: 700 ; Middle Aged ; Mortality ; Neoplasms - etiology ; Neoplasms - mortality ; Nutrition and Dietetics ; Nutrition research ; Näringslära ; Poisoning ; Prospective Studies ; Questionnaires ; Respiratory diseases ; Risk Assessment ; Samfunnsmedisin, sosialmedisin: 801 ; Smoking ; Time Factors ; VDP ; Womens health
Is Part Of: BMJ open, 2014-01, Vol.4 (7), p.e005245-e005245
Description: Objectives To investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death. Design The European Prospective Investigation into Cancer and nutrition (EPIC). Setting 23 centres in 10 countries. Participants 380 395 men and women, free of cancer, diabetes, heart attack or stroke at enrolment, followed up for 12.6 years on average. Main outcome measures 20 453 fatal events, of which 2053 alcohol-related cancers (ARC, including cancers of upper aerodigestive tract, liver, colorectal and female breast), 4187 cardiovascular diseases/coronary heart disease (CVD/CHD), 856 violent deaths and injuries. Lifetime alcohol use was assessed at recruitment. Results HRs comparing extreme drinkers (≥30 g/day in women and ≥60 g/day in men) to moderate drinkers (0.1–4.9 g/day) were 1.27 (95% CI 1.13 to 1.43) in women and 1.53 (1.39 to 1.68) in men. Strong associations were observed for ARC mortality, in men particularly, and for violent deaths and injuries, in men only. No associations were observed for CVD/CHD mortality among drinkers, whereby HRs were higher in never compared to moderate drinkers. Overall mortality seemed to be more strongly related to beer than wine use, particularly in men. The 10-year risks of overall death for women aged 60 years, drinking more than 30 g/day was 5% and 7%, for never and current smokers, respectively. Corresponding figures in men consuming more than 60 g/day were 11% and 18%, in never and current smokers, respectively. In competing risks analyses, mortality due to CVD/CHD was more pronounced than ARC in men, while CVD/CHD and ARC mortality were of similar magnitude in women. Conclusions In this large European cohort, alcohol use was positively associated with overall mortality, ARC and violent death and injuries, but marginally to CVD/CHD. Absolute risks of death observed in EPIC suggest that alcohol is an important determinant of total mortality.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 2044-6055
EISSN: 2044-6055
DOI: 10.1136/bmjopen-2014-005245
PMID: 24993766
Source: ProQuest One Psychology
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Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study

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