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Preparation of curcumin-loaded pluronic F127/chitosan nanoparticles for cancer therapy

Advances in natural sciences. Nanoscience and nanotechnology, 2013-03, Vol.4 (2), p.25001 [Peer Reviewed Journal]

2013 Vietnam Academy of Science & Technology ;ISSN: 2043-6262 ;EISSN: 2043-6262 ;DOI: 10.1088/2043-6262/4/2/025001 ;CODEN: ANSNCK

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  • Title:
    Preparation of curcumin-loaded pluronic F127/chitosan nanoparticles for cancer therapy
  • Author: Phuc Le, Thi Minh ; Pham, Van Phuc ; Lua Dang, Thi Minh ; Huyen La, Thi ; Le, Thi Hanh ; Le, Quang Huan
  • Subjects: chitosan ; curcumin ; ionic gelation ; pluronic
  • Is Part Of: Advances in natural sciences. Nanoscience and nanotechnology, 2013-03, Vol.4 (2), p.25001
  • Description: Nanoparticles (NPs) have been proven to be an effective delivery system with few side effects for anticancer drugs. In this study, curcumin-loaded NPs have been prepared by an ionic gelation method using chitosan (Chi) and pluronic®F-127 (PF) as carriers to deliver curcumin to the target cancer cells. Prepared NPs were characterized using Zetasizer, fluorescence microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Our results showed that the encapsulation efficiency of curcumin was approximately 50%. The average size of curcumin-loaded PF/Chi NPs was 150.9 nm, while the zeta potential was 5.09 mV. Cellular uptake of curcumin-loaded NPs into HEK293 cells was confirmed by fluorescence microscopy.
  • Publisher: IOP Publishing
  • Language: English
  • Identifier: ISSN: 2043-6262
    EISSN: 2043-6262
    DOI: 10.1088/2043-6262/4/2/025001
    CODEN: ANSNCK
  • Source: Open Access: IOP Publishing Free Content
    Geneva Foundation Free Medical Journals at publisher websites
    IOPscience (Open Access)
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