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Carbon monoxide poisoning and subsequent cardiovascular disease risk: a nationwide population-based cohort study

Medicine (Baltimore), 2015-03, Vol.94 (10), p.e624 [Peer Reviewed Journal]

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. 2015 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000000624 ;PMID: 25761191

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  • Title:
    Carbon monoxide poisoning and subsequent cardiovascular disease risk: a nationwide population-based cohort study
  • Author: Lee, Feng-You ; Chen, Wei-Kung ; Lin, Cheng-Li ; Kao, Chia-Hung
  • Subjects: Carbon Monoxide Poisoning - epidemiology ; Cardiovascular Diseases - epidemiology ; Cohort Studies ; Humans ; Incidence ; Observational Study ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Taiwan - epidemiology
  • Is Part Of: Medicine (Baltimore), 2015-03, Vol.94 (10), p.e624
  • Description: Carbon monoxide (CO) poisoning is considered one of the most crucial health concerns. Few studies have investigated the correlation between CO poisoning and the risk of developing cardiovascular diseases (CVDs). Therefore, we conducted a population-based, longitudinal cohort study in Taiwan to determine whether patients with CO poisoning are associated with higher risk of developing subsequent CVDs, including arrhythmia, coronary artery disease (CAD) and congestive heart failure (CHF). This retrospective study used the National Health Insurance Research Database. The study cohort comprised all patients aged ≥20 years with a diagnosis of CO poisoning and hospitalized during 2000 to 2011 (N = 8381), and the comparison cohort comprised randomly selected non-CO-poisoned patients (N = 33,524) frequency-matched with the study cohort by age, sex, and the year of index date. Each patient was individually tracked to identify those who develop CVD events during the follow-up period. Cox proportional hazards regression model was performed to calculate the hazard ratios of CVDs after adjusting for possible confounders. The overall incidences of arrhythmia, CAD, and CHF were higher in the patients with CO poisoning than in the controls (2.57 vs 1.25/1000 person-years, 3.28 vs 2.25/1000 person-years, and 1.32 vs 1.05/1000 person-years, respectively). After adjusting for age, sex, and comorbidities, the patients with CO poisoning were associated with a 1.83-fold higher risk of arrhythmia compared with the comparison cohort, and nonsignificantly associated with risk of CAD and CHF. CO-poisoned patients with coexisting comorbidity or in high severity were associated with significantly and substantially increased risk of all 3 CVDs. CO poisoning is associated with increased risk of subsequent development of arrhythmia. Future studies are required to explore the long-term effects of CO poisoning on the cardiovascular system.
  • Publisher: United States: Wolters Kluwer Health
  • Language: English
  • Identifier: ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000000624
    PMID: 25761191
  • Source: IngentaConnect Free/Open Access Journals
    Journals@Ovid Open Access Journal Collection Rolling
    Wolters Kluwer Open Health
    MEDLINE
    PubMed Central
    DOAJ Directory of Open Access Journals
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