Language:

Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis

The American journal of psychiatry, 2017-04, Vol.174 (4), p.319-328 [Peer Reviewed Journal]

Copyright © 2017 by the American Psychiatric Association 2017 ;ISSN: 0002-953X ;EISSN: 1535-7228 ;DOI: 10.1176/appi.ajp.2016.16020138 ;PMID: 27838934

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
Author: O’Donnell, Kieran J ; Meaney, Michael J
Subjects: Affect - physiology ; Birth Weight - genetics ; Birth Weight - physiology ; Brain - embryology ; Brain - physiopathology ; Child ; Child, Preschool ; Chronic Disease ; Female ; Fetal Development - genetics ; Fetal Development - physiology ; Fetal Growth Retardation - physiopathology ; Gene-Environment Interaction ; Glucocorticoids - blood ; Humans ; Infant ; Infant, Newborn ; Male ; Maternal Health ; Mental Disorders - embryology ; Mental Disorders - genetics ; Mental Disorders - physiopathology ; Neurodevelopmental Disorders - genetics ; Neurodevelopmental Disorders - physiopathology ; Pregnancy ; Prenatal Exposure Delayed Effects - genetics ; Prenatal Exposure Delayed Effects - physiopathology ; Psychopathology ; Risk Factors ; Stress, Psychological - complications ; Stress, Psychological - genetics ; Stress, Psychological - physiopathology ; Temperament - physiology
Is Part Of: The American journal of psychiatry, 2017-04, Vol.174 (4), p.319-328
Description: The quality of fetal growth and development predicts the risk for a range of noncommunicable, chronic illnesses. These observations form the basis of the “developmental origins of health and disease” hypothesis, which suggests that the intrauterine signals that compromise fetal growth also act to “program” tissue differentiation in a manner that predisposes to later illness. Fetal growth also predicts the risk for later psychopathology. These findings parallel studies showing that antenatal maternal emotional well-being likewise predicts the risk for later psychopathology. Taken together, these findings form the basis for integrative models of fetal neurodevelopment, which propose that antenatal maternal adversity operates through the biological pathways associated with fetal growth to program neurodevelopment. The authors review the literature and find little support for such integrated models. Maternal anxiety, depression, and stress all influence neurodevelopment but show modest, weak, or no associations with known stress mediators (e.g., glucocorticoids) or with fetal growth. Rather, compromised fetal development appears to establish a “meta-plastic” state that increases sensitivity to postnatal influences. There also remain serious concerns that observational studies associating either fetal growth or maternal mental health with neurodevelopmental outcomes fail to account for underlying genetic factors. Finally, while the observed relation between fetal growth and adult health has garnered considerable attention, the clinical relevance of these associations remains to be determined. There are both considerable promise and important challenges for future studies of the fetal origins of mental health.
Publisher: United States: American Psychiatric Association
Language: English
Identifier: ISSN: 0002-953X
EISSN: 1535-7228
DOI: 10.1176/appi.ajp.2016.16020138
PMID: 27838934
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis

Copyright © 2017 by the American Psychiatric Association 2017 ;ISSN: 0002-953X ;EISSN: 1535-7228 ;DOI: 10.1176/appi.ajp.2016.16020138 ;PMID: 27838934

Searching Remote Databases, Please Wait