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Maternal Glucose and LDL-Cholesterol Levels Are Related to Placental Leptin Gene Methylation, and, Together With Nutritional Factors, Largely Explain a Higher Methylation Level Among Ethnic South Asians

Frontiers in endocrinology (Lausanne), 2021-12, Vol.12, p.809916-809916 [Peer Reviewed Journal]

Copyright © 2021 Sletner, Moen, Yajnik, Lekanova, Sommer, Birkeland, Jenum and Böttcher. ;info:eu-repo/semantics/openAccess ;Copyright © 2021 Sletner, Moen, Yajnik, Lekanova, Sommer, Birkeland, Jenum and Böttcher 2021 Sletner, Moen, Yajnik, Lekanova, Sommer, Birkeland, Jenum and Böttcher ;ISSN: 1664-2392 ;EISSN: 1664-2392 ;DOI: 10.3389/fendo.2021.809916 ;PMID: 35002980

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  • Title:
    Maternal Glucose and LDL-Cholesterol Levels Are Related to Placental Leptin Gene Methylation, and, Together With Nutritional Factors, Largely Explain a Higher Methylation Level Among Ethnic South Asians
  • Author: Sletner, Line ; Moen, Aina E F ; Yajnik, Chittaranjan S ; Lekanova, Nadezhda ; Sommer, Christine ; Birkeland, Kåre I ; Jenum, Anne K ; Böttcher, Yvonne
  • Subjects: Adiposity - ethnology ; Adiposity - physiology ; Adult ; Asians - ethnology ; Blood Glucose - metabolism ; cholesterol ; Cholesterol, LDL - blood ; Cohort Studies ; Diabetes, Gestational - blood ; Diabetes, Gestational - ethnology ; DNA Methylation - physiology ; Endocrinology ; ethnicity ; Female ; Follow-Up Studies ; gestational diabetes ; Humans ; Leptin ; Leptin - metabolism ; methylation ; Nutritional Status - ethnology ; placenta ; Placenta - metabolism ; Pregnancy
  • Is Part Of: Frontiers in endocrinology (Lausanne), 2021-12, Vol.12, p.809916-809916
  • Description: Leptin, mainly secreted by fat cells, plays a core role in the regulation of appetite and body weight, and has been proposed as a mediator of metabolic programming. During pregnancy leptin is also secreted by the placenta, as well as being a key regulatory cytokine for the development, homeostatic regulation and nutrient transport within the placenta. South Asians have a high burden of type 2 diabetes, partly attributed to a "thin-fat-phenotype". Our aim was to investigate how maternal ethnicity, adiposity and glucose- and lipid/cholesterol levels in pregnancy are related to placental leptin gene ( ) DNA methylation. We performed DNA methylation analyses of 13 placental CpG sites in 40 ethnic Europeans and 40 ethnic South Asians participating in the STORK-Groruddalen cohort. South Asian ethnicity and gestational diabetes (GDM) were associated with higher placental methylation. The largest ethnic difference was found for CpG11 [5.8% (95% CI: 2.4, 9.2), p<0.001], and the strongest associations with GDM was seen for CpG5 [5.2% (1.4, 9.0), p=0.008]. Higher maternal LDL-cholesterol was associated with lower placental methylation, in particular for CpG11 [-3.6% (-5.5, -1.4) per one mmol/L increase in LDL, p<0.001]. After adjustments, including for nutritional factors involved in the one-carbon-metabolism cycle (vitamin D, B12 and folate levels), ethnic differences in placental methylation were strongly attenuated, while associations with glucose and LDL-cholesterol persisted. Maternal glucose and lipid metabolism is related to placental methylation, whilst metabolic and nutritional factors largely explain a higher methylation level among ethnic South Asians.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English;Norwegian
  • Identifier: ISSN: 1664-2392
    EISSN: 1664-2392
    DOI: 10.3389/fendo.2021.809916
    PMID: 35002980
  • Source: Directory of Open Access Scholarly Resources (ROAD)
    PubMed Central (Open access)
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    NORA Norwegian Open Research Archives
    DOAJ Directory of Open Access Journals
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