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Emerging role of HMGB1 in fibrotic diseases

Journal of cellular and molecular medicine, 2014-12, Vol.18 (12), p.2331-2339 [Peer Reviewed Journal]

2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. ;Copyright © 2014 John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine ;2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. 2014 ;ISSN: 1582-1838 ;EISSN: 1582-4934 ;DOI: 10.1111/jcmm.12419 ;PMID: 25284457

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Title:
Emerging role of HMGB1 in fibrotic diseases
Author: Li, Liu‐Cheng ; Gao, Jian ; Li, Jun
Subjects: Animals ; Antibodies - immunology ; Antibodies - therapeutic use ; cystic fibrosis ; Cystic Fibrosis - drug therapy ; Cystic Fibrosis - metabolism ; Cystic Fibrosis - physiopathology ; high‐mobility group box 1 ; HMGB1 Protein - antagonists & inhibitors ; HMGB1 Protein - immunology ; HMGB1 Protein - metabolism ; HMGB1 Protein - physiology ; Humans ; Liver Cirrhosis - drug therapy ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - physiopathology ; liver fibrosis ; Models, Biological ; Molecular Targeted Therapy ; myocardial fibrosis ; pulmonary fibrosis ; Pulmonary Fibrosis - drug therapy ; Pulmonary Fibrosis - metabolism ; Pulmonary Fibrosis - physiopathology ; renal fibrosis ; Reviews ; Signal Transduction - drug effects
Is Part Of: Journal of cellular and molecular medicine, 2014-12, Vol.18 (12), p.2331-2339
Description: High‐mobility group box 1 (HMGB1) is originally identified as a DNA‐binding protein that functions as a structural co‐factor critical for proper transcriptional regulation in somatic cells. Recent studies indicate that HMGB1 can be passively released from necrotic cells or actively secreted into the extracellular milieu under appropriate signal stimulation. Extracellular HMGB1 is a multifunctional cytokine that contributes to the process of infection, injury, inflammation, apoptosis, and immune responses by binding to specific cell‐surface receptors. Recently, emerging studies indicate that HMGB1 is closely involved in fibrotic disorders including cystic fibrosis, liver fibrosis and pulmonary fibrosis, while HMGB1 signal inhibitions protect against the experimental models of fibrotic diseases. From a clinical perspective, HMGB1 represents a current challenge that can be exploited orchestrate reparative responses. This review focuses on the crucial role of HMGB1 in the pathogenesis of fibrotic diseases and inhibition of which may represent a promising clinical approach for treating tissue fibrosis.
Publisher: England: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1582-1838
EISSN: 1582-4934
DOI: 10.1111/jcmm.12419
PMID: 25284457
Source: Journals@Ovid Open Access Journal Collection Rolling
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Wiley Online Library
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Emerging role of HMGB1 in fibrotic diseases

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