skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Mesenteric Responsiveness To Angiotensin I, II And Captopril During Renovascular Hypertension Induction

Majallah-i Danishkadah-'i Pizishki, 2003-08, Vol.61 (3), p.245-253 [Peer Reviewed Journal]

ISSN: 1683-1764 ;EISSN: 1735-7322

Full text available

Citations Cited by
  • Title:
    Mesenteric Responsiveness To Angiotensin I, II And Captopril During Renovascular Hypertension Induction
  • Author: Sharifi A M ; Heshmatian B ; Karimiam S M ; Akbarloo NNozary Y ; Ahmadi Kaliji
  • Subjects: Mesentric perfusion ; Renin Angiotensin system ; Two kidney-one clip Goldblatte Hypertension
  • Is Part Of: Majallah-i Danishkadah-'i Pizishki, 2003-08, Vol.61 (3), p.245-253
  • Description: Essential hypertension is one of the risk factors of cardiovascular diseases. Hypertension etiology is not completely known, it seems that rennin-Angiotensin system has an important role in its etiology, Thus better recognition of this system and its activity changes or vascular reaction changes to different parts of this system during progressive hypertension can be more effective in better recognition of the disease progress and treatment."nMaterials and Methods: In this study responsiveness of mesenteric vessels of Goldblatt two kidney- one clip (2k-lc) renovascular hypertensive rats to angiotensin / and II with and with out captopril during a time of two , four , six and eight weeks after hypertension induction was investigated and compared with control and surgical sham groups."nResults: This study shows that vascular responsiveness to angiotensin // in animals that passed four weeks of their hypertension , (p< 0.05) and in the sixth and eight week of post induction hypertension (p< 0.01 and p< 0.001) has a significant different with both sham and control groups. Also it has been observed that an increased reaction to angiotensin II with an increased significant rate of arterial hypertension in hypertensive group. In the other hand in spite of inhibition of angiotensin converting enzyme by captopril in animals that have been eight weeks hypertension , on the contrary to other groups reactive to angiotensin /."nConclusion: Results of this study show that vessels reaction to angiotensin /and II increased due to six to eight weeks post induction renal hypertension. Captopril does not inhibite mesenteric vessels reaction to Angiotensin / in hypertensive Rats after eight weeks. Try to completely inhibit production of angiotensin II maybe a hopful way in controlling essential hypertension.
  • Publisher: Tehran University of Medical Sciences
  • Language: Persian
  • Identifier: ISSN: 1683-1764
    EISSN: 1735-7322
  • Source: GFMER Free Medical Journals
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait