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Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

International journal of molecular medicine, 2015-12, Vol.36 (6), p.1451-1463 [Peer Reviewed Journal]

Copyright: © Li et al. ;COPYRIGHT 2015 Spandidos Publications ;Copyright: © Li et al. 2015 ;ISSN: 1107-3756 ;EISSN: 1791-244X ;DOI: 10.3892/ijmm.2015.2390 ;PMID: 26498181

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Title:
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)
Author: LI, JUN ; YE, LIN ; OWEN, SIONED ; WEEKS, HOI PING ; ZHANG, ZHONGTAO ; JIANG, WEN G
Subjects: Amino acids ; Angiogenesis ; Breast cancer ; cancers ; Carcinogenesis ; Carcinogenesis - genetics ; Carcinogenesis - metabolism ; CCN family proteins ; CCN Intercellular Signaling Proteins - genetics ; CCN Intercellular Signaling Proteins - metabolism ; Cell adhesion & migration ; cell functions ; Cellular signal transduction ; Colorectal cancer ; Connective Tissue Growth Factor - genetics ; Connective Tissue Growth Factor - metabolism ; Cysteine-Rich Protein 61 - genetics ; Cysteine-Rich Protein 61 - metabolism ; Genetic aspects ; Health aspects ; Humans ; Insulin ; Insulin-like growth factors ; Kinases ; Ligands ; Localization ; Metastasis ; Motility ; Neoplasm Metastasis ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Nephroblastoma Overexpressed Protein - genetics ; Nephroblastoma Overexpressed Protein - metabolism ; Ovarian cancer ; Prostate cancer ; Proteins ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; receptors ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; signalling pathways ; Tumorigenesis ; Tumors ; Vascular endothelial growth factor
Is Part Of: International journal of molecular medicine, 2015-12, Vol.36 (6), p.1451-1463
Description: The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.
Publisher: Greece: D.A. Spandidos
Language: English
Identifier: ISSN: 1107-3756
EISSN: 1791-244X
DOI: 10.3892/ijmm.2015.2390
PMID: 26498181
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

Copyright: © Li et al. ;COPYRIGHT 2015 Spandidos Publications ;Copyright: © Li et al. 2015 ;ISSN: 1107-3756 ;EISSN: 1791-244X ;DOI: 10.3892/ijmm.2015.2390 ;PMID: 26498181

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