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Young-Onset Diabetes in East Asians: From Epidemiology to Precision Medicine
Endocrinology and metabolism (Seoul), 2024-04, Vol.39 (2), p.239
[Peer Reviewed Journal]
ISSN: 2093-596X ;EISSN: 2093-5978
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Title:
Young-Onset Diabetes in East Asians: From Epidemiology to Precision Medicine
Author:
Juliana C. N. Chan
;
Chun-kwan O
;
Andrea O. Y. Luk
Subjects:
East Asians
;
Epidemiology
;
Precision medicine
;
Young-onset diabetes
Is Part Of:
Endocrinology and metabolism (Seoul), 2024-04, Vol.39 (2), p.239
Description:
Precision diagnosis is the keystone of clinical medicine. In East Asians, classical type 1 diabetes is uncommon in patients with youngonset diabetes diagnosed before age of 40, in whom a family history, obesity, and beta-cell and kidney dysfunction are key features. Young-onset diabetes affects one in five Asian adults with diabetes in clinic settings; however, it is often misclassified, resulting in delayed or non-targeted treatment. Complex aetiologies, long disease duration, aggressive clinical course, and a lack of evidence-based guidelines have contributed to variable care standards and premature death in these young patients. The high burden of comorbidities, notably mental illness, highlights the numerous knowledge gaps related to this silent killer. The majority of adult patients with youngonset diabetes are managed as part of a heterogeneous population of patients with various ages of diagnosis. A multidisciplinary care team led by physicians with special interest in young-onset diabetes will help improve the precision of diagnosis and address their physical, mental, and behavioral health. To this end, payors, planners, and providers need to align and re-design the practice environment to gather data systematically during routine practice to elucidate the multicausality of young-onset diabetes, treat to multiple targets, and improve outcomes in these vulnerable individuals.
Publisher:
대한내분비학회
Language:
Korean
Identifier:
ISSN: 2093-596X
EISSN: 2093-5978
Source:
Open Access: PubMed Central
KoreaMed Synapse(OpenAccess)
DOAJ Directory of Open Access Journals
KoreaMed Open Access
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