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Aquaporin 4: a player in cerebral edema and neuroinflammation

Journal of neuroinflammation, 2012-12, Vol.9 (1), p.279-279, Article 771 [Peer Reviewed Journal]

COPYRIGHT 2012 BioMed Central Ltd. ;2012 Fukuda and Badaut; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright ©2012 Fukuda and Badaut; licensee BioMed Central Ltd. 2012 Fukuda and Badaut; licensee BioMed Central Ltd. ;ISSN: 1742-2094 ;EISSN: 1742-2094 ;DOI: 10.1186/1742-2094-9-279 ;PMID: 23270503

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Title:
Aquaporin 4: a player in cerebral edema and neuroinflammation
Author: Fukuda, Andrew M ; Badaut, Jerome
Subjects: Animals ; Aquaporin ; Aquaporin 4 ; Aquaporin 4 - metabolism ; Aquaporins ; Astrocyte ; Astrocytes ; Autoimmune Diseases - complications ; Blood brain barrier ; Blood-Brain Barrier - physiopathology ; Brain ; Brain damage ; Brain diseases ; Brain Edema - etiology ; Brain Edema - metabolism ; Brain Edema - pathology ; Brain Injuries - complications ; Cell adhesion & migration ; Cerebral edema ; Cytokines ; Edema ; Encephalitis - etiology ; Encephalitis - metabolism ; Encephalitis - pathology ; Gliosis ; Homeostasis ; Humans ; Hypertrophy ; Inflammation ; Injuries ; Magnetic Resonance Imaging ; Microglia ; Molecular weight ; Neuroglia - metabolism ; Neuroglia - pathology ; Neuroinflammation ; Proteins ; Review ; Stroke ; Stroke (Disease) ; Traumatic brain injury
Is Part Of: Journal of neuroinflammation, 2012-12, Vol.9 (1), p.279-279, Article 771
Description: Neuroinflammation is a common pathological event observed in many different brain diseases, frequently associated with blood brain barrier (BBB) dysfunction and followed by cerebral edema. Neuroinflammation is characterized with microglia activation and astrogliosis, which is a hypertrophy of the astrocytes. Astrocytes express aquaporin 4, the water channel protein, involved in water homeostasis and edema formation. Aside from its function in water homeostasis, recent studies started to show possible interrelations between aquaporin 4 and neuroinflammation. In this review the roles of aquaporin 4 in neuroinflammation associated with BBB disruption and cerebral edema will be discussed with recent studies in the field.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1742-2094
EISSN: 1742-2094
DOI: 10.1186/1742-2094-9-279
PMID: 23270503
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Springer Nature OA/Free Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Aquaporin 4: a player in cerebral edema and neuroinflammation

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