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Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

Allergy, 2020-07, Vol.75 (7), p.1730 [Peer Reviewed Journal]

2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. ;2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://novel-coronavirus.onlinelibrary.wiley.com ;EISSN: 1398-9995 ;DOI: 10.1111/all.14238 ;PMID: 32077115

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Title:
Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China
Author: Zhang, Jin-Jin ; Dong, Xiang ; Cao, Yi-Yuan ; Yuan, Ya-Dong ; Yang, Yi-Bin ; Yan, You-Qin ; Akdis, Cezmi A ; Gao, Ya-Dong
Subjects: Adult ; Aged ; Aged, 80 and over ; Betacoronavirus - genetics ; C-Reactive Protein - analysis ; China - epidemiology ; Community-Acquired Infections ; Comorbidity ; Coronavirus Infections - blood ; Coronavirus Infections - epidemiology ; Coronavirus Infections - physiopathology ; Coronavirus Infections - virology ; COVID-19 ; Diabetes Mellitus - epidemiology ; Eosinophils ; Female ; Hospitalization ; Humans ; Hypertension - epidemiology ; Lymphopenia ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral - blood ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - physiopathology ; Pneumonia, Viral - virology ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
Is Part Of: Allergy, 2020-07, Vol.75 (7), p.1730
Description: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were community-acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001). Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.
Publisher: Denmark: John Wiley & Sons, Inc
Language: English
Identifier: EISSN: 1398-9995
DOI: 10.1111/all.14238
PMID: 32077115
Source: Coronavirus Research Database

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Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

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