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Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Frontiers in pharmacology, 2021-01, Vol.11, p.592654 [Peer Reviewed Journal]

Copyright © 2021 Salehi, Quispe, Chamkhi, El Omari, Balahbib, Sharifi-Rad, Bouyahya, Akram, Iqbal, Docea, Caruntu, Leyva-Gómez, Dey, Martorell, Calina, López and Les. ;COPYRIGHT 2021 Frontiers Research Foundation ;Copyright © 2021 Salehi, Quispe, Chamkhi, El Omari, Balahbib, Sharifi-Rad, Bouyahya, Akram, Iqbal, Docea, Caruntu, Leyva-Gómez, Dey, Martorell, Calina, López and Les. 2021 Salehi, Quispe, Chamkhi, El Omari, Balahbib, Sharifi-Rad, Bouyahya, Akram, Iqbal, Docea, Caruntu, Leyva-Gómez, Dey, Martorell, Calina, López and Les ;ISSN: 1663-9812 ;EISSN: 1663-9812 ;DOI: 10.3389/fphar.2020.592654 ;PMID: 33536909

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  • Title:
    Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
  • Author: Salehi, Bahare ; Quispe, Cristina ; Chamkhi, Imane ; El Omari, Nasreddine ; Balahbib, Abdelaali ; Sharifi-Rad, Javad ; Bouyahya, Abdelhakim ; Akram, Muhammad ; Iqbal, Mehwish ; Docea, Anca Oana ; Caruntu, Constantin ; Leyva-Gómez, Gerardo ; Dey, Abhijit ; Martorell, Miquel ; Calina, Daniela ; López, Víctor ; Les, Francisco
  • Subjects: bioavailability ; chalcones ; clinical trials ; flavonoids ; Medical research ; Medicine, Experimental ; molecular mechanisms ; pharmacological studies ; Pharmacology
  • Is Part Of: Frontiers in pharmacology, 2021-01, Vol.11, p.592654
  • Description: Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules.
  • Publisher: Switzerland: Frontiers Research Foundation
  • Language: English
  • Identifier: ISSN: 1663-9812
    EISSN: 1663-9812
    DOI: 10.3389/fphar.2020.592654
    PMID: 33536909
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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