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Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats

Drug design, development and therapy, 2019-01, Vol.13, p.71-77 [Peer Reviewed Journal]

COPYRIGHT 2019 Dove Medical Press Limited ;2019. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 Zhang et al. This work is published and licensed by Dove Medical Press Limited 2019 ;ISSN: 1177-8881 ;EISSN: 1177-8881 ;DOI: 10.2147/DDDT.S186029 ;PMID: 30587929

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Title:
Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats
Author: Zhang, Qi ; Nie, Jing ; Chen, Su-Juan ; Li, Qiang
Subjects: acute lung injury ; Acute Lung Injury - chemically induced ; Acute Lung Injury - metabolism ; Acute Lung Injury - pathology ; Acute Lung Injury - prevention & control ; Acute respiratory distress syndrome ; Alveoli ; Animals ; Bronchus ; Capillary Permeability - drug effects ; Content analysis ; Disease Models, Animal ; Drug dosages ; Drugs, Chinese Herbal - pharmacology ; Edema ; ethyl gallate ; Food ; Gallic Acid - analogs & derivatives ; Gallic Acid - pharmacology ; Humidity ; Hydrolyzable Tannins - pharmacology ; Identification methods ; Injuries ; Laboratory animals ; Leukocytes ; Leukocytes (neutrophilic) ; Leukocytes (polymorphonuclear) ; Lipopolysaccharides ; Lung - drug effects ; Lung - metabolism ; Lung - pathology ; Lungs ; Male ; Mitogens ; Neutrophil Infiltration - drug effects ; NMR ; Nuclear magnetic resonance ; Original Research ; pentagalloylglucose ; Pretreatment ; Principal components analysis ; Pulmonary Edema - chemically induced ; Pulmonary Edema - metabolism ; Pulmonary Edema - pathology ; Pulmonary Edema - prevention & control ; Qingwen Baidu Decoction ; Rats, Sprague-Dawley ; Respiratory distress syndrome ; Respiratory therapy ; Rodents ; Swine flu ; Trachea ; Tumor necrosis factor-TNF ; White blood cells
Is Part Of: Drug design, development and therapy, 2019-01, Vol.13, p.71-77
Description: The aim of this study was to investigate the bioactive constituents of Qingwen Baidu Decoction (QBD) in a rat model of acute lung injury (ALI) induced by lipopolysaccharide (LPS). Our previous studies showed that ethyl gallate (EG) and pentagalloylglucose (PGG) were the active components of QBD for the treatment of ALI. We isolated two compounds and identified the structures of them by nuclear magnetic resonance and mass spectrometer. Lung injury was induced by intratracheal instillation with LPS (5 mg/kg). Rats were randomly divided into six groups: Control group; LPS group; 5 mL/kg DEX + LPS group; 6.6 g/kg QBD extract + LPS group; 17.16 mg/kg PGG + LPS group; 7.26 mg/kg EG + LPS group. The effects of compounds on LPS-induced the number of total cells, neutrophils influx, protein leakage, W/D weight ratio and pulmonary histological changes were examined. The results demonstrated that pretreatment with EG and PGG could notably inhibit lung edema and attenuate the pulmonary histological changes ( <0.05). The pretreatment also decreased the number of total cells and polymorphonuclear leukocytes in bronchoalveolar lavage fluid (BALF) ( <0.05). Ethyl gallate and pentagalloylglucose of QBD played a protective role in preventing LPS-induced ALI. The results supported further study of EG and PGG as potential candidates for preventing ALI.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1177-8881
EISSN: 1177-8881
DOI: 10.2147/DDDT.S186029
PMID: 30587929
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
DOVE Medical Press Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats

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