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The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017

The lancet oncology, 2019-09, Vol.20 (9), p.1211-1225 [Peer Reviewed Journal]

The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license ;2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license ;Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. ;2019. The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. This work is published under https://creativecommons.org/licenses/by/3.0/ (theLicense”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license 2019 ;ISSN: 1470-2045 ;ISSN: 1474-5488 ;EISSN: 1474-5488 ;DOI: 10.1016/S1470-2045(19)30339-0 ;PMID: 31371206

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Title:
The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017
Author: Agius, Dominic ; Alam, Tahiya ; Alipour, Vahid ; Allen, Christine A. ; Almasi-Hashiani, Amir ; Amini, Saeed ; Amoako, Yaw Ampem ; Anber, Nahla Hamed ; Arabloo, Jalal ; Artaman, Al ; Awasthi, Ashish ; Basaleem, Huda ; Bekru, Eyasu Tamru ; Bijani, Ali ; Bogale, Kassawmar Angaw ; Car, Mate ; Carvalho, Félix ; Chu, Dinh-Toi ; Costa, Vera M ; Demis, Asmamaw Bizuneh ; Dharmaratne, Samath Dhamminda ; Do, Huyen Phuc ; Doan, Linh Phuong ; El-Khatib, Ziad ; Emamian, Mohammad Hassan ; Farhangi, Mahdieh Abbasalizad ; Fernandes, Eduarda ; Fouladi Fard, Reza ; Friedrich, Paola M ; Fukumoto, Takeshi ; Gedefaw, Getnet Azeze ; Ghashghaee, Ahmad ; Gholamian, Asadollah ; Hamidi, Samer ; Hay, Simon I. ; Hole, Michael K. ; Hosseini, Seyyed Nasrollah ; Hsairi, Mohamed ; Hudson, Melissa Maria ; Kasaeian, Amir ; Kassebaum, Nicholas J ; Keiyoro, Peter Njenga ; Kianipour, Neda ; Lauriola, Paolo ; Manafi, Navid ; Massenburg, Benjamin Ballard ; Mehta, Varshil ; Meretoja, Tuomo J ; Mestrovic, Tomislav ; Mohammad, Dara K. ; Mohammadoo-Khorasani, Milad ; Mokdad, Ali H ; Moosazadeh, Mahmood ; Moradpour, Farhad ; Naghavi, Mohsen ; Nazari, Javad ; Ngunjiri, Josephine W. ; Nguyen, Cuong Tat ; Nguyen, Son Hoang ; Nguyen, Trang Huyen ; Nixon, Molly R ; Olagunju, Andrew T ; Ong, Sok King ; Pennini, Alyssa ; Pereira, David M. ; Pillay, Julian David ; Qorbani, Mostafa ; Rabiee, Mohammad ; Raoofi, Samira ; Rawaf, David Laith ; Rawaf, Salman ; Rezaei, Nima ; Rezapour, Aziz ; Roba, Kedir Teji ; Robison, Les L. ; Safiri, Saeid ; Salahshoor, Mohamadreza ; Samy, Abdallah M. ; Santric Milicevic, Milena M ; Satpathy, Maheswar ; Sawyer, Susan M ; Seyedmousavi, Seyedmojtaba ; Shabaninejad, Hosein ; Shirkoohi, Reza ; Siabani, Soraya ; Singh, Jasvinder A. ; SiRamlee, Khairil ; Tabarés-Seisdedos, Rafael ; Tran, Bach Xuan ; Vahedian-Azimi, Amir ; Vos, Theo ; Waheed, Yasir ; Workie, Hailemariam Mekonnen ; Yaseri, Mehdi ; Zadnik, Vesna ; Zahirian Moghadam, Telma ; Ziapour, Arash ; Zodpey, Sanjay ; Murray, Christopher J L ; Fitzmaurice, Christina
Subjects: Adolescent ; Adult ; Age ; Age Distribution ; Autopsy ; Cancer ; Cause of Death ; Child ; Child, Preschool ; Children ; Disabled Persons ; Disease ; Female ; Global Burden of Disease ; Global Health ; Health risk assessment ; Hematology, Oncology, and Palliative Medicine ; Humans ; Infant ; Infant, Newborn ; Injuries ; Leukemia ; Life Expectancy ; Life span ; Lymphoma ; Male ; Medicin och hälsovetenskap ; Mortality ; Neoplasms - epidemiology ; Neoplasms - mortality ; Neoplasms - pathology ; Partnership agreements ; Registration ; Risk Factors ; Socioeconomic Factors ; Studies ; Young Adult
Is Part Of: The lancet oncology, 2019-09, Vol.20 (9), p.1211-1225
Description: SummaryBackgroundAccurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). MethodsUsing the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0–19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final point estimates are reported with 95% uncertainty intervals. FindingsGlobally, in 2017, there were 11·5 million (95% uncertainty interval 10·6–12·3) DALYs due to childhood cancer, 97·3% (97·3–97·3) of which were attributable to YLLs and 2·7% (2·7–2·7) of which were attributable to YLDs. Childhood cancer was the sixth leading cause of total cancer burden globally and the ninth leading cause of childhood disease burden globally. 82·2% (82·1–82·2) of global childhood cancer DALYs occurred in low, low-middle, or middle Socio-demographic Index locations, whereas 50·3% (50·3–50·3) of adult cancer DALYs occurred in these same locations. Cancers that are uncategorised in the current GBD framework comprised 26·5% (26·5–26·5) of global childhood cancer DALYs. InterpretationThe GBD 2017 results call attention to the substantial burden of childhood cancer globally, which disproportionately affects populations in resource-limited settings. The use of DALY-based estimates is crucial in demonstrating that childhood cancer burden represents an important global cancer and child health concern. FundingBill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities (ALSAC), and St. Baldrick's Foundation.
Publisher: England: Elsevier Ltd
Language: English
Identifier: ISSN: 1470-2045
ISSN: 1474-5488
EISSN: 1474-5488
DOI: 10.1016/S1470-2045(19)30339-0
PMID: 31371206
Source: MEDLINE
SWEPUB Freely available online
ProQuest Central

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The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017

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