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0217 Chronic and Acute Sleep Restriction Does Not Adversely Influence Testosterone Concentrations in Young Healthy Males

Sleep (New York, N.Y.), 2019-04, Vol.42 (Supplement_1), p.A89-A89 [Peer Reviewed Journal]

Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. ;ISSN: 0161-8105 ;EISSN: 1550-9109 ;DOI: 10.1093/sleep/zsz067.216

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  • Title:
    0217 Chronic and Acute Sleep Restriction Does Not Adversely Influence Testosterone Concentrations in Young Healthy Males
  • Author: Smith, Isaac ; Salazar, Ismel ; St-Onge, Marie-Pierre
  • Subjects: Health risk assessment ; Sleep ; Testosterone
  • Is Part Of: Sleep (New York, N.Y.), 2019-04, Vol.42 (Supplement_1), p.A89-A89
  • Description: Introduction Low testosterone concentrations in men increases the risk for physical, psychological, and cognitive disorders. Despite sleep being the period when the majority of testosterone production occurs, there is little information on how sleep influences testosterone concentrations. The primary goal of the present study was to examine the effects of SR on circulating testosterone levels. We hypothesized that both severe SR and milder, sustained SR would lead to reductions in circulating testosterone concentrations in healthy young males. Methods Study 1: Fourteen men participated in an inpatient, randomized, crossover study of habitual sleep (HS; 9 h time in bed [TIB]) or SR (4 h TIB) for 5 nights. Plasma testosterone levels were measured at baseline and endpoint. Study 2: Thirteen men participated in a randomized, crossover outpatient study of HS or SR (HS-1.5 h) for 6 wk. Plasma testosterone was assessed at baseline, wk 3, and wk 6 of each phase. Linear model analyses to assess the effects of SR on testosterone were performed separately for each study. Results Study 1: There was no significant sleep-time interaction on testosterone concentrations (change in testosterone levels during HS=22.86±163.79ng/dL; SR=43.73±159.96 ng/dL,P=0.41) and no main effect of sleep duration (P=0.13).Study 2: There was a trend for a sleep-time interaction (P=0.067) and a main effect of sleep on testosterone concentrations from 6 wk of SR (P=0.0046). Testosterone concentrations were slightly lower but increased over time with SR relative to HS. Conclusion SR does not adversely affect plasma testosterone levels in healthy young men. Given prior contradicting evidence, confirmatory studies should be done to ascertain the influence of sleep duration and quality on testosterone concentrations in men throughout life. Support (If Any) Study 1was funded by NIH grant R01HL091352 and Study 2was funded by NIH grant R01HL128226 (both St-Onge, PI). Studies were in part supported by an NIH Clinical and Translational Science Award (CTSA) through its Center for Advancing Translational Sciences, grant no. UL1TR001873.
  • Publisher: Westchester: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0161-8105
    EISSN: 1550-9109
    DOI: 10.1093/sleep/zsz067.216
  • Source: ProQuest One Psychology
    Alma/SFX Local Collection
    ProQuest Central
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