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Rapid evolution of sex pheromone-producing enzyme expression in Drosophila

PLoS biology, 2009-08, Vol.7 (8), p.e1000168-e1000168 [Peer Reviewed Journal]

Shirangi et al. 2009 ;2009 Shirangi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Shirangi TR, Dufour HD, Williams TM, Carroll SB (2009) Rapid Evolution of Sex Pheromone-Producing Enzyme Expression in Drosophila. PLoS Biol 7(8): e1000168. doi:10.1371/journal.pbio.1000168 ;ISSN: 1545-7885 ;ISSN: 1544-9173 ;EISSN: 1545-7885 ;DOI: 10.1371/journal.pbio.1000168 ;PMID: 19652700

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Title:
Rapid evolution of sex pheromone-producing enzyme expression in Drosophila
Author: Shirangi, Troy R ; Dufour, Héloïse D ; Williams, Thomas M ; Carroll, Sean B
Eisen, Michael B.
Subjects: Animal Communication ; Animal reproduction ; Animals ; Behavior ; Binding sites ; Binding Sites - genetics ; Colleges & universities ; Deoxyribonucleic acid ; Developmental Biology ; Developmental Biology/Developmental Evolution ; Developmental Biology/Developmental Molecular Mechanisms ; Developmental Biology/Molecular Development ; DNA ; DNA-Binding Proteins - genetics ; Drosophila ; Drosophila - enzymology ; Drosophila melanogaster ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Enzymes ; Evolution, Molecular ; Evolutionary Biology ; Evolutionary Biology/Developmental Evolution ; Evolutionary Biology/Developmental Molecular Mechanisms ; Evolutionary Biology/Sexual Behavior ; Fatty Acid Desaturases - genetics ; Fatty Acid Desaturases - metabolism ; Female ; Females ; Gene Expression Regulation - genetics ; Genetics ; Genetics and Genomics/Gene Expression ; In Situ Hybridization ; Insects ; Male ; Males ; Mating Preference, Animal - physiology ; Molecular Biology ; Molecular Biology/Molecular Evolution ; Pheromones ; Proteins ; Sex Attractants - biosynthesis ; Sex Characteristics ; Sexual Behavior, Animal - physiology
Is Part Of: PLoS biology, 2009-08, Vol.7 (8), p.e1000168-e1000168
Description: A wide range of organisms use sex pheromones to communicate with each other and to identify appropriate mating partners. While the evolution of chemical communication has been suggested to cause sexual isolation and speciation, the mechanisms that govern evolutionary transitions in sex pheromone production are poorly understood. Here, we decipher the molecular mechanisms underlying the rapid evolution in the expression of a gene involved in sex pheromone production in Drosophilid flies. Long-chain cuticular hydrocarbons (e.g., dienes) are produced female-specifically, notably via the activity of the desaturase DESAT-F, and are potent pheromones for male courtship behavior in Drosophila melanogaster. We show that across the genus Drosophila, the expression of this enzyme is correlated with long-chain diene production and has undergone an extraordinary number of evolutionary transitions, including six independent gene inactivations, three losses of expression without gene loss, and two transitions in sex-specificity. Furthermore, we show that evolutionary transitions from monomorphism to dimorphism (and its reversion) in desatF expression involved the gain (and the inactivation) of a binding-site for the sex-determination transcription factor, DOUBLESEX. In addition, we documented a surprising example of the gain of particular cis-regulatory motifs of the desatF locus via a set of small deletions. Together, our results suggest that frequent changes in the expression of pheromone-producing enzymes underlie evolutionary transitions in chemical communication, and reflect changing regimes of sexual selection, which may have contributed to speciation among Drosophila.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1545-7885
ISSN: 1544-9173
EISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000168
PMID: 19652700
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Rapid evolution of sex pheromone-producing enzyme expression in Drosophila

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