Language:

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9950-9955 [Peer Reviewed Journal]

copyright © 1993-2008 National Academy of Sciences of the United States of America ;2015 INIST-CNRS ;Copyright National Academy of Sciences Jun 11, 2013 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1305814110 ;PMID: 23671070 ;CODEN: PNASA6

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Author: Li, Jun Z. ; Bunney, Blynn G. ; Meng, Fan ; Hagenauer, Megan H. ; Walsh, David M. ; Vawter, Marquis P. ; Evans, Simon J. ; Choudary, Prabhakara V. ; Cartagena, Preston ; Barchas, Jack D. ; Schatzberg, Alan F. ; Jones, Edward G. ; Myers, Richard M. ; Watson, Stanley J. ; Akil, Huda ; Bunney, William E.
Subjects: Adult ; Adult and adolescent clinical studies ; Aged ; ARNTL Transcription Factors ; Autopsy ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Biological and medical sciences ; Biological Sciences ; Brain ; Brain - metabolism ; Circadian Clocks - genetics ; Circadian rhythm ; Circadian Rhythm - genetics ; Correlations ; Depression ; Depressive Disorder, Major - genetics ; Depressive disorders ; Female ; Gene expression ; Gene Expression Profiling ; Genes ; Homeodomain Proteins - genetics ; Humans ; Major depressive disorder ; Male ; Medical sciences ; Mental depression ; Middle Aged ; Mood disorders ; Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics ; Oligonucleotide Array Sequence Analysis ; P values ; Period Circadian Proteins - genetics ; Prefrontal cortex ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sleep
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9950-9955
Description: A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain were difficult to characterize. Here, we applied time-of-death analysis to gene expression data from high-quality postmortem brains, examining 24-h cyclic patterns in six cortical and limbic regions of 55 subjects with no history of psychiatric or neurological illnesses (“controls”) and 34 patients with MDD. Our dataset covered ∼12,000 transcripts in the dorsolateral prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, nucleus accumbens, and cerebellum. Several hundred transcripts in each region showed 24-h cyclic patterns in controls, and >100 transcripts exhibited consistent rhythmicity and phase synchrony across regions. Among the top-ranked rhythmic genes were the canonical clock genes BMAL1(ARNTL), PER1-2-3, NR1D1(REV-ERBa), DBP, BHLHE40 (DEC1) , and BHLHE41(DEC2) . The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in the brains of patients with MDD due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggests potentially important molecular targets for treatment of mood disorders.
Publisher: Washington, DC: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1305814110
PMID: 23671070
CODEN: PNASA6
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

copyright © 1993-2008 National Academy of Sciences of the United States of America ;2015 INIST-CNRS ;Copyright National Academy of Sciences Jun 11, 2013 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1305814110 ;PMID: 23671070 ;CODEN: PNASA6

Searching Remote Databases, Please Wait