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Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea

Marine drugs, 2019-09, Vol.17 (9), p.529 [Peer Reviewed Journal]

2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 by the authors. 2019 ;ISSN: 1660-3397 ;EISSN: 1660-3397 ;DOI: 10.3390/md17090529 ;PMID: 31510079

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Title:
Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea
Author: Cao, Duc Danh ; Trinh, Thi Thanh Van ; Mai, Huong Doan Thi ; Vu, Van Nam ; Le, Hong Minh ; Thi, Quyen Vu ; Nguyen, Mai Anh ; Duong, Thu Trang ; Tran, Dang Thach ; Chau, Van Minh ; Ma, Rui ; Shetye, Gauri ; Cho, Sanghyun ; Murphy, Brian T ; Pham, Van Cuong
Subjects: actinomycete ; Animals ; anti-microbial ; anti-tuberculosis ; Antibiotics, Antitubercular - chemistry ; Antibiotics, Antitubercular - isolation & purification ; Antibiotics, Antitubercular - pharmacology ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Carbon ; Cell Line, Tumor ; Circular Dichroism ; Cotton ; cytotoxicity ; Data analysis ; Dichroism ; Disease resistance ; flavonoid ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Ionization ; Magnetic Resonance Spectroscopy ; Mass spectrometry ; Mass spectroscopy ; Metabolites ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Molecular Structure ; Mycobacterium tuberculosis - drug effects ; NMR ; Nuclear magnetic resonance ; Porifera - microbiology ; Spectrometry, Mass, Electrospray Ionization ; Streptomyces ; Streptomyces - chemistry ; Tuberculosis ; Two dimensional analysis ; Vietnam
Is Part Of: Marine drugs, 2019-09, Vol.17 (9), p.529
Description: Three new lavandulylated flavonoids, (2 ,2'' )-6-lavandulyl-7,4'-dimethoxy-5,2'-dihydroxylflavanone ( ), (2 ,2'' )-6-lavandulyl-5,7,2',4'-tetrahydroxylflavanone ( ), and (2'' )-5'-lavandulyl-2'-methoxy-2,4,4',6'-tetrahydroxylchalcone ( ), along with seven known compounds were isolated from culture broth of s sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of were resolved by comparison of their experimental and calculated electronic circular dichroism spectra. Compounds exhibited remarkable antimicrobial activity. Whereas, two known compounds and exhibited inhibitory activity against H37Rv with minimum inhibitory concentration (MIC) values of 6.0 µg/mL and 11.1 µg/mL, respectively.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1660-3397
EISSN: 1660-3397
DOI: 10.3390/md17090529
PMID: 31510079
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea

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