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Impact of Flavonols on Cardiometabolic Biomarkers: A Meta-Analysis of Randomized Controlled Human Trials to Explore the Role of Inter-Individual Variability

Nutrients, 2017-02, Vol.9 (2), p.117 [Peer Reviewed Journal]

Copyright MDPI AG 2017 ;cc-by (c) Menezes, Regina et al., 2017 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es ;Copyright ;2017 by the authors. 2017 ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu9020117 ;PMID: 28208791

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Title:
Impact of Flavonols on Cardiometabolic Biomarkers: A Meta-Analysis of Randomized Controlled Human Trials to Explore the Role of Inter-Individual Variability
Author: Menezes, Regina ; Rodriguez-Mateos, Ana ; Kaltsatou, Antonia ; González-Sarrías, Antonio ; Greyling, Arno ; Giannaki, Christoforos ; Andres-Lacueva, Cristina ; Milenkovic, Dragan ; Gibney, Eileen R ; Dumont, Julie ; Schär, Manuel ; Garcia-Aloy, Mar ; Palma-Duran, Susana Alejandra ; Ruskovska, Tatjana ; Maksimova, Viktorija ; Combet, Emilie ; Pinto, Paula
Subjects: Adult ; Asia ; Biomarkers ; Biomarkers - blood ; Blood lipids ; Blood Pressure ; blood lipids ; blood pressure ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; cardiovascular disease ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Consumption ; Dietary Supplements ; Epidemiology ; Female ; Flavonoides ; Flavonoids ; Flavonols ; Flavonols - administration & dosage ; Food and Nutrition ; Glucose ; Health risk assessment ; Heart diseases ; Humans ; Interindividual variability ; Life Sciences ; Lipids ; Lipids - blood ; Lípids de la sang ; Malalties cardiovasculars ; Male ; Meta-analysis ; Metaanàlisi ; Middle Aged ; Nutrients ; Physiological responses ; Pressió sanguínia ; quercetin ; Randomization ; Randomized Controlled Trials as Topic ; Review ; Risk ; Risk Factors ; Santé publique et épidémiologie ; Subgroups ; Suplements nutritius ; systematic review ; Triglycerides
Is Part Of: Nutrients, 2017-02, Vol.9 (2), p.117
Description: Several epidemiological studies have linked flavonols with decreased risk of cardiovascular disease (CVD). However, some heterogeneity in the individual physiological responses to the consumption of these compounds has been identified. This meta-analysis aimed to study the effect of flavonol supplementation on biomarkers of CVD risk such as, blood lipids, blood pressure and plasma glucose, as well as factors affecting their inter-individual variability. Data from 18 human randomized controlled trials were pooled and the effect was estimated using fixed or random effects meta-analysis model and reported as difference in means (DM). Variability in the response of blood lipids to supplementation with flavonols was assessed by stratifying various population subgroups: age, sex, country, and health status. Results showed significant reductions in total cholesterol (DM = -0.10 mmol/L; 95% CI: -0.20, -0.01), LDL cholesterol (DM = -0.14 mmol/L; Nutrients 2017, 9, 117 2 of 21 95% CI: -0.21, 0.07), and triacylglycerol (DM = -0.10 mmol/L; 95% CI: -0.18, 0.03), and a significant increase in HDL cholesterol (DM = 0.05 mmol/L; 95% CI: 0.02, 0.07). A significant reduction was also observed in fasting plasma glucose (DM = -0.18 mmol/L; 95%CI: -0.29, -0.08), and in blood pressure (SBP: DM = -4.84 mmHg; 95% CI: -5.64, -4.04; DBP: DM = -3.32 mmHg; 95% CI: -4.09, -2.55). Subgroup analysis showed a more pronounced effect of flavonol intake in participants from Asian countries and in participants with diagnosed disease or dyslipidemia, compared to healthy and normal baseline values. In conclusion, flavonol consumption improved biomarkers of CVD risk, however, country of origin and health status may influence the effect of flavonol intake on blood lipid levels.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 2072-6643
EISSN: 2072-6643
DOI: 10.3390/nu9020117
PMID: 28208791
Source: Recercat
Geneva Foundation Free Medical Journals at publisher websites
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Impact of Flavonols on Cardiometabolic Biomarkers: A Meta-Analysis of Randomized Controlled Human Trials to Explore the Role of Inter-Individual Variability

Copyright MDPI AG 2017 ;cc-by (c) Menezes, Regina et al., 2017 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es ;Copyright ;2017 by the authors. 2017 ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu9020117 ;PMID: 28208791

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