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Review of the neurological benefits of phytocannabinoids

Surgical neurology international, 2018-01, Vol.9 (1), p.91-91

2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright: © 2018 Surgical Neurology International 2018 ;ISSN: 2152-7806 ;ISSN: 2229-5097 ;EISSN: 2152-7806 ;DOI: 10.4103/SNI.SNI_45_18 ;PMID: 29770251

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  • Title:
    Review of the neurological benefits of phytocannabinoids
  • Author: Maroon, Joseph ; Bost, Jeff
  • Subjects: Alzheimers disease ; Brain research ; FDA approval ; General Neurosurgery: Review ; Hemp ; Medical marijuana ; Pain ; Parkinsons disease ; Pharmaceutical industry ; Stockholders
  • Is Part Of: Surgical neurology international, 2018-01, Vol.9 (1), p.91-91
  • Description: Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia. The phytocannabinoids, cannabidiol (CBD), and delta-9-tetrahydrocannabinol (Δ9-THC) are the most studied extracts from cannabis sativa subspecies hemp and marijuana. CBD and Δ9-THC interact uniquely with the endocannabinoid system (ECS). Through direct and indirect actions, intrinsic endocannabinoids and plant-based phytocannabinoids modulate and influence a variety of physiological systems influenced by the ECS. Methods: In 1980, Cunha et al. reported anticonvulsant benefits in 7/8 subjects with medically uncontrolled epilepsy using marijuana extracts in a phase I clinical trial. Since then neurological applications have been the major focus of renewed research using medical marijuana and phytocannabinoid extracts. Results: Recent neurological uses include adjunctive treatment for malignant brain tumors, Parkinson's disease, Alzheimer's disease, multiple sclerosis, neuropathic pain, and the childhood seizure disorders Lennox-Gastaut and Dravet syndromes. In addition, psychiatric and mood disorders, such as schizophrenia, anxiety, depression, addiction, postconcussion syndrome, and posttraumatic stress disorders are being studied using phytocannabinoids. Conclusions: In this review we will provide animal and human research data on the current clinical neurological uses for CBD individually and in combination with Δ9-THC. We will emphasize the neuroprotective, antiinflammatory, and immunomodulatory benefits of phytocannabinoids and their applications in various clinical syndromes.
  • Publisher: Pittsford: Wolters Kluwer India Pvt. Ltd
  • Language: English
  • Identifier: ISSN: 2152-7806
    ISSN: 2229-5097
    EISSN: 2152-7806
    DOI: 10.4103/SNI.SNI_45_18
    PMID: 29770251
  • Source: GFMER Free Medical Journals
    PubMed Central
    ProQuest Central
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