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Subclinical Tuberculosis Disease-A Review and Analysis of Prevalence Surveys to Inform Definitions, Burden, Associations, and Screening Methodology

Clinical infectious diseases, 2021-08, Vol.73 (3), p.e830-e841 [Peer Reviewed Journal]

The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. ;The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. 2020 ;ISSN: 1058-4838 ;EISSN: 1537-6591 ;DOI: 10.1093/cid/ciaa1402 ;PMID: 32936877

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  • Title:
    Subclinical Tuberculosis Disease-A Review and Analysis of Prevalence Surveys to Inform Definitions, Burden, Associations, and Screening Methodology
  • Author: Frascella, Beatrice ; Richards, Alexandra S ; Sossen, Bianca ; Emery, Jon C ; Odone, Anna ; Law, Irwin ; Onozaki, Ikushi ; Esmail, Hanif ; Houben, Rein M G J
  • Subjects: Humans ; Mass Screening ; Online Only ; Prevalence ; Surveys and Questionnaires ; Thorax ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology
  • Is Part Of: Clinical infectious diseases, 2021-08, Vol.73 (3), p.e830-e841
  • Description: While it is known that a substantial proportion of individuals with tuberculosis disease (TB) present subclinically, usually defined as bacteriologically-confirmed but negative on symptom screening, considerable knowledge gaps remain. Our aim was to review data from TB prevalence population surveys and generate a consistent definition and framework for subclinical TB, enabling us to estimate the proportion of TB that is subclinical, explore associations with overall burden and program indicators, and evaluate the performance of screening strategies. We extracted data from all publicly available prevalence surveys conducted since 1990. Between 36.1% and 79.7% (median, 50.4%) of prevalent bacteriologically confirmed TB was subclinical. No association was found between prevalence of subclinical and all bacteriologically confirmed TB, patient diagnostic rate, or country-level HIV prevalence (P values, .32, .4, and .34, respectively). Chest Xray detected 89% (range, 73%-98%) of bacteriologically confirmed TB, highlighting the potential of optimizing current TB case-finding policies.
  • Publisher: United States: Oxford University Press
  • Language: English
  • Identifier: ISSN: 1058-4838
    EISSN: 1537-6591
    DOI: 10.1093/cid/ciaa1402
    PMID: 32936877
  • Source: MEDLINE
    Alma/SFX Local Collection
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