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Pycnogenol registered Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome

Phytotherapy research, 2013-10, Vol.27 (10), p.1572-1578 [Peer Reviewed Journal]

ISSN: 0951-418X ;EISSN: 1099-1573 ;DOI: 10.1002/ptr.4883

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  • Title:
    Pycnogenol registered Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome
  • Author: Belcaro, G ; Cornelli, U ; Luzzi, R ; Dugall, M ; Feragalli, B ; Errichi, S ; Ippolito, E ; Grossi, M G ; Hosoi, M ; Cornelli, M ; Gizzi, G
  • Subjects: Bark
  • Is Part Of: Phytotherapy research, 2013-10, Vol.27 (10), p.1572-1578
  • Description: This open, controlled study evaluated the effects of 6month supplementation with Pycnogenol registered maritime pine bark extract on health risk factors in subjects with metabolic syndrome. Pycnogenol registered was used with the aim of improving risk factors associated with metabolic syndrome, central obesity, elevated triglycerides (TG), low HDL cholesterol, high blood pressure and fasting blood glucose. Sixty-four subjects (range 45-55years) presenting with all five risk factors of metabolic syndrome were included, and Pycnogenol registered was administered for 6months. A group of 66 equivalent subjects were followed up as controls. In the 6-month study Pycnogenol registered supplementation 150mg/day decreased waist circumference, TG levels, blood pressure and increased the HDL cholesterol levels in subjects. Pycnogenol lowered fasting glucose from baseline 123 plus or minus 8.6mg/dl to 106.4 plus or minus 5.3 after 3months and to 105.3 plus or minus 2.5 at the end of the study (p<0.05 vs controls). Men's waist circumference decreased with Pycnogenol from 106.2 plus or minus 2.2cm to 98.8 plus or minus 2.3cm and to 98.3 plus or minus 2.1 after 3 and 6months. Women's waist decreased from 90.9 plus or minus 1.6cm to 84.6 plus or minus 2.1cm and to 83.6 plus or minus 2.2cm after 3 and 6months. Both genders waist circumference reduction was significant as compared to controls at both time points. In addition, plasma free radicals decrease in the Pycnogenol group was more effective than in the control group (-34.6%; p<0.05). In conclusion, this study indicates a role for Pycnogenol registered for improving health risk factors in subjects with metabolic syndrome. Copyright [copy 2013 John Wiley & Sons, Ltd.
  • Language: English
  • Identifier: ISSN: 0951-418X
    EISSN: 1099-1573
    DOI: 10.1002/ptr.4883
  • Source: Alma/SFX Local Collection
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