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Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome

Nature immunology, 2017-07, Vol.18 (8), p.861-869 [Peer Reviewed Journal]

ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.3772 ;PMID: 28722711

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Title:
Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome
Author: Afonina, Inna S ; Zhong, Zhenyu ; Karin, Michael ; Beyaert, Rudi
Subjects: Alternative Splicing ; Feedback, Physiological ; Humans ; Inflammasomes - immunology ; Inflammation - immunology ; NF-kappa B - immunology ; NLR Family, Pyrin Domain-Containing 3 Protein - immunology ; Protein Processing, Post-Translational ; RNA Processing, Post-Transcriptional ; Signal Transduction ; Ubiquitination
Is Part Of: Nature immunology, 2017-07, Vol.18 (8), p.861-869
Description: A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-κB pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.
Publisher: United States
Language: English
Identifier: ISSN: 1529-2908
EISSN: 1529-2916
DOI: 10.1038/ni.3772
PMID: 28722711
Source: MEDLINE
ProQuest Central

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Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome

ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.3772 ;PMID: 28722711

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