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Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms

Anesthesia and analgesia, 2016-05, Vol.122 (5), p.1546-1553 [Peer Reviewed Journal]

2016 International Anesthesia Research Society ;ISSN: 0003-2999 ;EISSN: 1526-7598 ;DOI: 10.1213/ANE.0000000000001195 ;PMID: 27101499

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Title:
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms
Author: Sultan, Pervez ; David, Anna L ; Fernando, Roshan ; Ackland, Gareth L
Subjects: Analgesia, Epidural - adverse effects ; Analgesia, Obstetrical - adverse effects ; Anesthetics, Local - adverse effects ; Animals ; Female ; Fever - chemically induced ; Fever - immunology ; Fever - metabolism ; Fever - therapy ; Humans ; Inflammasomes - immunology ; Inflammasomes - metabolism ; Inflammation - chemically induced ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - therapy ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Obstetric Labor Complications - chemically induced ; Obstetric Labor Complications - immunology ; Obstetric Labor Complications - metabolism ; Obstetric Labor Complications - therapy ; Pregnancy ; Prognosis ; Risk Factors ; Signal Transduction
Is Part Of: Anesthesia and analgesia, 2016-05, Vol.122 (5), p.1546-1553
Description: Intrapartum fever is associated with excessive maternal interventions as well as higher neonatal morbidity. Epidural-related maternal fever (ERMF) contributes to the development of intrapartum fever. The mechanism(s) for ERMF has remained elusive. Here, we consider how inflammatory mechanisms may be modulated by local anesthetic agents and their relevance to ERMF. We also critically reappraise the clinical data with regard to emerging concepts that explain how anesthetic drug–induced metabolic dysfunction, with or without activation of the inflammasome, might trigger the release of nonpathogenic, inflammatory molecules (danger-associated molecular patterns) likely to underlie ERMF.
Publisher: United States: International Anesthesia Research Society
Language: English
Identifier: ISSN: 0003-2999
EISSN: 1526-7598
DOI: 10.1213/ANE.0000000000001195
PMID: 27101499
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms

2016 International Anesthesia Research Society ;ISSN: 0003-2999 ;EISSN: 1526-7598 ;DOI: 10.1213/ANE.0000000000001195 ;PMID: 27101499

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