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Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis

Scientific reports, 2021-03, Vol.11 (1), p.6283-6283, Article 6283 [Peer Reviewed Journal]

The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-021-85359-3 ;PMID: 33737527

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  • Title:
    Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
  • Author: Ssentongo, Paddy ; Heilbrunn, Emily S ; Ssentongo, Anna E ; Advani, Shailesh ; Chinchilli, Vernon M ; Nunez, Jonathan J ; Du, Ping
  • Subjects: Acquired immune deficiency syndrome ; AIDS ; Antiretroviral therapy ; Chronic infection ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - mortality ; Disease Susceptibility ; Epidemiology ; HIV ; HIV Infections - complications ; Human immunodeficiency virus ; Humans ; Immune system ; Infections ; Meta-analysis ; Mortality ; Proteinase inhibitors ; Risk factors ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Systematic review ; Tenofovir
  • Is Part Of: Scientific reports, 2021-03, Vol.11 (1), p.6283-6283, Article 6283
  • Description: Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk of mortality among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA) is largely unknown. PLWHA are unique due to their altered immune system from their history of chronic HIV infection and their use of antiretroviral therapy, some of which have been used experimentally to treat coronavirus disease 2019 (COVID-19). Therefore, we conducted a systematic review and meta-analysis to assess the epidemiology of SARS-COV-2/HIV coinfection and estimate associated mortality from COVID-19 (Prospero Registration ID: CRD42020187980). PubMed, SCOPUS, OVID and Cochrane Library databases, and medRxiv preprint repositories were searched from January 1, 2020, to December 12, 2020. Data were extracted from studies reporting COVID-19 attack and mortality rates in PLWHA compared to their HIV-negative counterparts. Pooled attack and mortality risks were quantified using random-effects models. We identified 22 studies that included 20,982,498 participants across North America, Africa, Europe, and Asia. The median age was 56 years, and 50% were male. HIV-positive persons had a significantly higher risk of SARS-CoV-2 infection [risk ratio (RR) 1.24, 95% CI 1.05-1.46)] and mortality from COVID-19 (RR 1.78, 95% CI 1.21-2.60) than HIV-negative individuals. The beneficial effects of tenofovir and protease-inhibitors in reducing the risk of SARS-CoV-2 infection and death from COVID-19 in PLWHA remain inconclusive. HIV remains a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality from COVID-19. In support of the current Centers for Disease Control and Prevention (CDC) guidelines, persons with HIV need priority consideration for the SARS-CoV-2 vaccine.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/s41598-021-85359-3
    PMID: 33737527
  • Source: MEDLINE
    PubMed Central
    Coronavirus Research Database
    ProQuest Central
    DOAJ Directory of Open Access Journals
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