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Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations
Endocrinology and metabolism (Seoul), 2020-12, Vol.35 (4), p.681-695
[Peer Reviewed Journal]
COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED ;ISSN: 2093-596X ;EISSN: 2093-5978
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Title:
Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations
Author:
Rachel Williams
;
Muthu Periasamy
Subjects:
Adiposity
;
Asian
;
Intra-abdominal fat
Is Part Of:
Endocrinology and metabolism (Seoul), 2020-12, Vol.35 (4), p.681-695
Description:
Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity―the “skinny-fat” Asian syndrome. In this review, we critically evaluate the relative roles of genetics and environmental factors on fat distribution in Asian populations. While there is an upward trend in obesity among most Asian countries, it appears particularly conspicuous in Malaysia. We propose a novel theory, the Malaysian gene-environment multiplier hypothesis, which explains how ancestral variations in feast-and-famine cycles contribute to inherited genetic predispositions that, when acted on by modern-day stressors―most notably, urbanization, westernization, lifestyle changes, dietary transitions, cultural pressures, and stress―contribute to increased visceral adiposity in Asian populations. At present, the major determinants contributing to visceral adiposity in Asians are far from conclusive, but we seek to highlight critical areas for further research.
Publisher:
대한내분비학회
Language:
Korean
Identifier:
ISSN: 2093-596X
EISSN: 2093-5978
Source:
KoreaMed Synapse
PubMed Central
KoreaMed Open Access
DOAJ Directory of Open Access Journals
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