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Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat

Endocrinology and metabolism (Seoul), 2021-08, Vol.36 (4), p.835-844 [Peer Reviewed Journal]

COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED ;ISSN: 2093-596X ;EISSN: 2093-5978

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  • Title:
    Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
  • Author: Sun Ok Song ; You-cheol Hwang ; Han Uk Ryu ; Steven E. Kahn ; Donna L. Leonetti ; Wilfred Y. Fujimoto ; Edward J. Boyko
  • Subjects: Asian Americans ; Cholesterol ; Epidemiology ; HDL ; Intra-abdominal fat
  • Is Part Of: Endocrinology and metabolism (Seoul), 2021-08, Vol.36 (4), p.835-844
  • Description: Background: Both intra-abdominal fat (IAF) and high-density lipoprotein cholesterol (HDL-C) are known to be associated with cardiometabolic health. We evaluated whether the accumulation of computed tomography (CT)-measured IAF over 5 years was related to baseline HDL-C concentration in a prospective cohort study. Methods: All participants were Japanese-Americans between the ages of 34 and 74 years. Plasma HDL-C concentration and CT measurements of IAF, abdominal subcutaneous fat (SCF), and thigh SCF cross-sectional areas were assessed at baseline and at 5-year follow-up visits. Results: A total of 397 subjects without diabetes were included. The meanstandard deviation HDL-C concentration was 51.6 13.0 mg/dL in men and 66.017.0 mg/dL in women, and the IAF was 91.948.4 cm2 in men and 63.1 39.5 cm2 in women. The baseline plasma concentration of HDL-C was inversely associated with the change in IAF over 5 years using multivariable regression analysis with adjustment for age, sex, family history of diabetes, weight change over 5 years, and baseline measurements of body mass index, IAF, abdominal SCF, abdominal circumference, thigh SCF, and homeostatic model assessment for insulin resistance. Conclusion: These results demonstrate that HDL-C concentration significantly predicts future accumulation of IAF over 5 years in-dependent of age, sex, insulin sensitivity, and body composition in Japanese-American men and women without diabetes.
  • Publisher: 대한내분비학회
  • Language: Korean
  • Identifier: ISSN: 2093-596X
    EISSN: 2093-5978
  • Source: KoreaMed Synapse
    PubMed Central
    KoreaMed Open Access
    DOAJ Directory of Open Access Journals
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