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Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance

PloS one, 2020-10, Vol.15 (10), p.e0240174-e0240174 [Peer Reviewed Journal]

COPYRIGHT 2020 Public Library of Science ;COPYRIGHT 2020 Public Library of Science ;2020 Gupta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Attribution ;2020 Gupta et al 2020 Gupta et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0240174 ;PMID: 33075062

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Title:
Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance
Author: Gupta, Himanshu ; Galatas, Beatriz ; Chidimatembue, Arlindo ; Huijben, Silvie ; Cisteró, Pau ; Matambisso, Gloria ; Nhamussua, Lidia ; Simone, Wilson ; Bassat, Quique ; Ménard, Didier ; Ringwald, Pascal ; Rabinovich, N Regina ; Alonso, Pedro L ; Saúte, Francisco ; Aide, Pedro ; Mayor, Alfredo
Carvalho, Luzia Helena
Subjects: Analysis ; Antimalarials ; Antimalarials - administration & dosage ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Antimicrobial agents ; Artemisinin ; Artemisinins ; Artemisinins - administration & dosage ; Artemisinins - pharmacology ; Artemisinins - therapeutic use ; Biological markers ; Biology and Life Sciences ; Deoxyribonucleic acid ; Dihydroartemisinin ; DNA ; Dosage and administration ; Drug Combinations ; Drug Resistance ; Drug Resistance - genetics ; Epidemiology ; Hospitals ; Human health and pathology ; Infectious diseases ; Life Sciences ; Malaria ; Malaria - parasitology ; Malaria - prevention & control ; Markers ; Medicine and Health Sciences ; Microbiology and Parasitology ; Mozambique ; Mutation ; Parasites ; Parasitology ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Plasmodium falciparum - genetics ; Plasmodium falciparum - pathogenicity ; Polymorphism, Genetic ; Population ; Protozoan Proteins ; Protozoan Proteins - genetics ; Protozoan Proteins - metabolism ; Public health ; Quinolines ; Quinolines - administration & dosage ; Quinolines - pharmacology ; Quinolines - therapeutic use ; Risk factors ; Statistical analysis ; Tropical diseases
Is Part Of: PloS one, 2020-10, Vol.15 (10), p.e0240174-e0240174
Description: Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associated with antimalarial resistance (k13, pfpm2, pfmdr1 and pfcrt) in Pf isolates collected before (n = 99) and after (n = 112) the implementation of two monthly MDA rounds with dihydroartemisinin-piperaquine (DHAp) for two consecutive years in Magude district of Southern Mozambique. None of the k13 polymorphisms associated with artemisinin resistance were observed in the Pf isolates analyzed. The proportion of Pf isolates with multiple copies of pfpm2, an amplification associated with piperaquine resistance, was similar in pre- (4.9%) and post-MDA groups (3.4%; p = 1.000). No statistically significant differences were observed between pre- and post-MDA groups in the proportion of Pf isolates neither with mutations in pfcrt and pfmdr1 genes, nor with the carriage of pfmdr1 multiple copies (p>0.05). This study does not show any evidence of increased frequency of molecular makers of antimalarial resistance after MDA with DHAp in southern Mozambique where markers of antimalarial resistance were absent or low at the beginning of the intervention.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0240174
PMID: 33075062
Source: Hyper Article en Ligne (HAL) (Open Access)
GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance

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