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Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China

BMC genetics, 2012-07, Vol.13 (1), p.61-61 [Peer Reviewed Journal]

2012 Zhang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright ©2012 Zhang et al.; licensee BioMed Central Ltd. 2012 Zhang et al.; licensee BioMed Central Ltd. ;ISSN: 1471-2156 ;ISSN: 1471-2350 ;EISSN: 1471-2350 ;EISSN: 1471-2156 ;DOI: 10.1186/1471-2350-13-61 ;PMID: 22849376

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Title:
Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China
Author: Zhang, Shuang-yan ; Xu, Mei-ling ; Zhang, Cui-e ; Qu, Zheng-yi ; Zhang, Bin-bin ; Zheng, Zu-yan ; Zhang, Li-ming
Subjects: 5-Lipoxygenase-Activating Proteins - genetics ; Adult ; Aged ; Alleles ; ALOX5AP ; Asian Continental Ancestry Group - genetics ; Cerebral infarction ; Cerebral Infarction - complications ; Cerebral Infarction - genetics ; China ; Confidence intervals ; Diabetes ; Diabetes Complications ; Disease ; Female ; FLAP ; Gene Frequency ; Genotype ; Genotype & phenotype ; Han ethnicity ; Haplotypes ; Heart attacks ; Humans ; Hypertension - complications ; Male ; Metabolic disorders ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors ; SNP ; Standard deviation ; Statistical analysis ; Stroke ; Studies
Is Part Of: BMC genetics, 2012-07, Vol.13 (1), p.61-61
Description: To explore the association of ALOX5AP single nucleotide polymorphisms (SNPs) and haplotype with the occurrence of cerebral infarction in the Han population of northern China. Blood samples were collected from 236 patients of Han ancestry with a history of cerebral infarction and 219 healthy subjects of Han ancestry with no history of cerebral infarction or cardiovascular disease. Applied Biosystems(®) TaqMan(®) SNP Genotyping Assays for SNP genotyping were used to determine the genotypes of 7 ALOX5AP SNP alleles (rs4073259, rs4769874, rs9315050, rs9551963, rs10507391, rs9579646, and rs4147064). One SNP allele (A) of rs4073259 was significantly associated with development of cerebral infarction (P = 0.049). In comparison to control groups, haplotype rs9315050&rs9551963 AAAC [OR (95% CI) = 1.53 (1.02-2.29)], and genotypes rs4147064 CT [OR (95% CI) = 1.872 (1.082-3.241)], and rs9551963 AC [OR (95% CI) = 2.015 (1.165-3.484)] increased the risk of cerebral infarction in patients with hypertension. Genotype rs9579646 GG [OR (95% CI) = 2.926 (1.18-7.251)] increased the risk of, while rs4073259 GG [OR (95% CI) = 0.381 (0.157-0.922)] decreased the risk of cerebral infarction in patients with diabetes. These results suggest the ALOX5AP SNP A allele in rs4073259 and genotype rs9579646 GG, rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with an increased risk of ischemic stroke in the Han population, while rs4073259 GG was associated with a decreased risk.
Publisher: England: BioMed Central
Language: English
Identifier: ISSN: 1471-2156
ISSN: 1471-2350
EISSN: 1471-2350
EISSN: 1471-2156
DOI: 10.1186/1471-2350-13-61
PMID: 22849376
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Springer Nature OA/Free Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China

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