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Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

Frontiers in pharmacology, 2020-05, Vol.11, p.697-697 [Peer Reviewed Journal]

Copyright © 2020 Xie, Bi, Zhang, Dong, Teng, Lee and Yang. ;COPYRIGHT 2020 Frontiers Research Foundation ;Copyright © 2020 Xie, Bi, Zhang, Dong, Teng, Lee and Yang 2020 Xie, Bi, Zhang, Dong, Teng, Lee and Yang ;ISSN: 1663-9812 ;EISSN: 1663-9812 ;DOI: 10.3389/fphar.2020.00697 ;PMID: 32508641

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  • Title:
    Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application
  • Author: Xie, Jing ; Bi, Ye ; Zhang, Huan ; Dong, Shiyan ; Teng, Lesheng ; Lee, Robert J ; Yang, Zhaogang
  • Subjects: Care and treatment ; cell-penetrating peptides ; cellular uptake ; Diagnosis ; Eye diseases ; Medical research ; Medicine, Experimental ; Nervous system diseases ; Peptides ; Pharmacology ; targeting ; translocate
  • Is Part Of: Frontiers in pharmacology, 2020-05, Vol.11, p.697-697
  • Description: Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have been predominantly used in basic and preclinical research during the last 30 years. Since they are not only capable of translocating themselves into cells but also facilitate drug or CPP/cargo complexes to translocate across the plasma membrane, they have potential applications in the disease diagnosis and therapy, including cancer, inflammation, central nervous system disorders, otologic and ocular disorders, and diabetes. However, no CPPs or CPP/cargo complexes have been approved by the US Food and Drug Administration (FDA). Many issues should be addressed before translating CPPs into clinics. In this review, we summarize recent developments and innovations in preclinical studies and clinical trials based on using CPP for improved delivery, which have revealed that CPPs or CPP-based delivery systems present outstanding diagnostic therapeutic delivery potential.
  • Publisher: Switzerland: Frontiers Research Foundation
  • Language: English
  • Identifier: ISSN: 1663-9812
    EISSN: 1663-9812
    DOI: 10.3389/fphar.2020.00697
    PMID: 32508641
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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