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Fungal infections in HIV/AIDS

The Lancet infectious diseases, 2017-11, Vol.17 (11), p.e334-e343 [Peer Reviewed Journal]

2017 Elsevier Ltd ;Copyright © 2017 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited Nov 1, 2017 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1473-3099 ;EISSN: 1474-4457 ;DOI: 10.1016/S1473-3099(17)30303-1 ;PMID: 28774701

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Title:
Fungal infections in HIV/AIDS
Author: Limper, Andrew H ; Adenis, Antoine ; Le, Thuy ; Harrison, Thomas S
Subjects: Acquired immune deficiency syndrome ; AIDS ; AIDS-Related Opportunistic Infections - diagnosis ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - epidemiology ; AIDS-Related Opportunistic Infections - microbiology ; Amphotericin B ; Antifungal Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; CD4 antigen ; Cryptococcosis ; Diagnostic systems ; Diagnostic Tests, Routine - methods ; Disease control ; Drug resistance ; Drugs ; Epidemiology ; Flucytosine ; Fungal diseases ; Fungi ; Fungi - classification ; Fungi - isolation & purification ; Fungicides ; Histoplasmosis ; HIV ; HIV Infections - complications ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; Incidence ; Infections ; Life Sciences ; Mycoses - diagnosis ; Mycoses - drug therapy ; Mycoses - epidemiology ; Mycoses - microbiology ; Patients ; Penicillium ; Pneumocystosis ; Point-of-Care Systems ; Santé publique et épidémiologie ; Talaromyces
Is Part Of: The Lancet infectious diseases, 2017-11, Vol.17 (11), p.e334-e343
Description: Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or re-present with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both. Affordable, rapid point-of-care diagnostic tests (as have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and histoplasmosis. Additionally, antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available. Such measures, together with continued international efforts in education and training in the management of fungal disease, have the potential to improve patient outcomes substantially.
Publisher: United States: Elsevier Ltd
Language: English
Identifier: ISSN: 1473-3099
EISSN: 1474-4457
DOI: 10.1016/S1473-3099(17)30303-1
PMID: 28774701
Source: Hyper Article en Ligne (HAL) (Open Access)
MEDLINE
ProQuest Central

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Fungal infections in HIV/AIDS

2017 Elsevier Ltd ;Copyright © 2017 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited Nov 1, 2017 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1473-3099 ;EISSN: 1474-4457 ;DOI: 10.1016/S1473-3099(17)30303-1 ;PMID: 28774701

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