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Modulation of NO production by arginase in the rabbit lower urinary tract

Journal of Pharmacological Sciences, 2003, Vol.91 (suppl.2), p.270-270 [Peer Reviewed Journal]

ISSN: 1347-8613 ;EISSN: 1347-8648

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  • Title:
    Modulation of NO production by arginase in the rabbit lower urinary tract
  • Author: Masataka Yano ; Hitoshi Masuda ; Keizo Kawano ; Yasuyuki Sakai ; Kazunori Kihara ; Emi Kurosaki ; Yukinao Yamauchi ; Hiroshi Azuma
  • Is Part Of: Journal of Pharmacological Sciences, 2003, Vol.91 (suppl.2), p.270-270
  • Description: Objective: We examined whether endogenous arginase is expressed and can play a functional role in regulating neurogenic and NO-mediated relaxation in the rabbit lower urinary tract. Methods: Strips of detrusor, trigone, proximal urethra and prostate obtained from Japanese white male rabbits weighing approximately 3. 0Kg were processed for organ bath studies and arginase activity. Results: Electrical field stimulation (EFS) induced nonadrenergic and noncholinergic (NANC) nerve- mediated relaxation in the trigone, proximal urethra and prostate, while no relaxation response was observed in the detrusor. These relaxations were inhibited by NG-nitro-L- arginine (L-NOARG) as a NOS inhibitor and enhanced by N-hydroxy-L-arginine (NOHA) as an arginase inhibitor in a concentration-dependent manner. The inhibition with L- NOARG was reversed by NOHA as well as L-arginine. The rank order of arginase activity was prostate, urethra, trigone and detrusorIn all regions, 100μM NOHA caused approximately 95% inhibition of arginase activity, while the L-NOARG (100μM) had no effect. Conclusion: These results indicate that the endogenous arginase plays a counteracting role in modulating NOS activity in lower urinary tract.
  • Publisher: The Japanese Pharmacological Society
  • Language: Japanese
  • Identifier: ISSN: 1347-8613
    EISSN: 1347-8648
  • Source: GFMER Free Medical Journals
    ROAD: Directory of Open Access Scholarly Resources
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