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MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

Scientific reports, 2017-08, Vol.7 (1), p.9262-9, Article 9262 [Peer Reviewed Journal]

2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2017 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-017-10167-7 ;PMID: 28835693

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Title:
MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
Author: Krauskopf, Julian ; de Kok, Theo M ; Hebels, Dennie G ; Bergdahl, Ingvar A ; Johansson, Anders ; Spaeth, Florentin ; Kiviranta, Hannu ; Rantakokko, Panu ; Kyrtopoulos, Soterios A ; Kleinjans, Jos C
Subjects: Adult ; Biodegradation ; Cancer ; Case-Control Studies ; Circulating MicroRNA ; Computational Biology - methods ; Congeners ; DDE ; DDT ; DNA microarrays ; Environmental Exposure - adverse effects ; Environmental Pollutants ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Health risk assessment ; Hexachlorobenzene ; Humans ; MicroRNAs ; MicroRNAs - blood ; MicroRNAs - genetics ; Middle Aged ; miRNA ; Myc protein ; Neoplasms - genetics ; p53 Protein ; PCB ; Pesticides ; Pollutants ; Polychlorinated biphenyls ; Risk Assessment ; Transcriptome ; Tumor suppressor genes ; Wnt protein
Is Part Of: Scientific reports, 2017-08, Vol.7 (1), p.9262-9, Article 9262
Description: Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and dichlorodiphenyltrichloroethane (DDT) have been classified as carcinogenic to humans and animals. Due to their resistance to biodegradation humans are still exposed to these compounds worldwide. We aim to evaluate the miRNA and transcriptomic response of a human population exposed to POPs. The miRNA and transcriptomic response was measured in blood of healthy subjects by microarray technology and associated with the serum concentrations of six PCB congeners, DDE (a common DDT metabolite), and HCB. A total of 93 miRNA levels appeared significantly associated with the POP-exposure (FDR < 0.05). The miRNA profile includes four tumor suppressor miRNAs, namely miR-193a-3p, miR-152, miR-31-5p and miR-34a-5p. Integration of the miRNA profile with the transcriptome profile suggests an interaction with oncogenes such as MYC, CCND1, BCL2 and VEGFA. We have shown that exposure to POPs is associated with human miRNA and transcriptomic responses. The identified miRNAs and target genes are related to various types of cancer and involved in relevant signaling pathways like wnt and p53. Therefore, these miRNAs may have great potential to contribute to biomarker-based environmental health risk assessment.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/s41598-017-10167-7
PMID: 28835693
Source: PubMed (Medline)
DAOJ: Directory of Open Access Journals
AUTh Library subscriptions: ProQuest Central
MEDLINE
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MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

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