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Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice

BMC neuroscience, 2016-08, Vol.17 (1), p.60, Article 60 [Peer Reviewed Journal]

COPYRIGHT 2016 BioMed Central Ltd. ;The Author(s) 2016 ;ISSN: 1471-2202 ;EISSN: 1471-2202 ;DOI: 10.1186/s12868-016-0295-2 ;PMID: 27581370

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Title:
Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice
Author: Zhang, Mingkun ; Cui, Zhenwen ; Cui, Hua ; Cao, Yang ; Zhong, Chunlong ; Wang, Yong
Subjects: Analysis ; Animals ; Aquaporin 4 - metabolism ; Astaxanthin ; Brain ; Brain - drug effects ; Brain - metabolism ; Brain - pathology ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Edema - metabolism ; Brain Edema - pathology ; Brain Injuries, Traumatic - complications ; Brain Injuries, Traumatic - drug therapy ; Brain Injuries, Traumatic - metabolism ; Brain Injuries, Traumatic - pathology ; Bumetanide - pharmacology ; Capillary Permeability - drug effects ; Capillary Permeability - physiology ; Complications and side effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Dropsy ; Drug Evaluation, Preclinical ; Economic aspects ; Edema ; Health aspects ; Injuries ; Male ; Mice, Inbred C57BL ; Neuroprotective Agents - pharmacology ; Physiology, Pathological ; Random Allocation ; Risk factors ; RNA, Messenger - metabolism ; Sodium Potassium Chloride Symporter Inhibitors - pharmacology ; Solute Carrier Family 12, Member 2 - metabolism ; Xanthophylls - pharmacology
Is Part Of: BMC neuroscience, 2016-08, Vol.17 (1), p.60, Article 60
Description: Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential neuroprotective properties for the treatment of central nervous system diseases, such as ischemic brain injury and subarachnoid hemorrhage. This study explored whether astaxanthin is neuroprotective and ameliorates neurological deficits following traumatic brain injury (TBI). Our results showed that, following CCI, treatment with astaxanthin compared to vehicle ameliorated neurologic dysfunctions after day 3 and alleviated cerebral edema and Evans blue extravasation at 24 h (p < 0.05). Astaxanthin treatment decreased AQP4 and NKCC1 mRNA levels in a dose-dependent manner at 24 h. AQP4 and NKCC1 protein expressions in the peri-contusional cortex were significantly reduced by astaxanthin at 24 h (p < 0.05). Furthermore, we also found that bumetanide (BU), an inhibitor of NKCC1, inhibited trauma-induced AQP4 upregulation (p < 0.05). Our data suggest that astaxanthin reduces TBI-related injury in brain tissue by ameliorating AQP4/NKCC1-mediated cerebral edema and that NKCC1 contributes to the upregulation of AQP4 after TBI.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2202
EISSN: 1471-2202
DOI: 10.1186/s12868-016-0295-2
PMID: 27581370
Source: ProQuest One Psychology
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Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice

COPYRIGHT 2016 BioMed Central Ltd. ;The Author(s) 2016 ;ISSN: 1471-2202 ;EISSN: 1471-2202 ;DOI: 10.1186/s12868-016-0295-2 ;PMID: 27581370

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