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Protective effect of dexmedetomidine on pulmonary edema with hemorrhagic shock in rats exposed to plateau environment

Lu jun jun yi da xue xue bao, 2023-12, Vol.45 (24), p.2570-2578 [Peer Reviewed Journal]

ISSN: 2097-0927 ;DOI: 10.16016/j.2097-0927.202307057

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  • Title:
    Protective effect of dexmedetomidine on pulmonary edema with hemorrhagic shock in rats exposed to plateau environment
  • Author: WANG Yi ; WANG Yi ; ZHU Yu ; TANG Chunqiong ; TANG Chunqiong
  • Subjects: dexmedetomidine ; hemorrhagic shock ; high altitude ; pulmonary edema
  • Is Part Of: Lu jun jun yi da xue xue bao, 2023-12, Vol.45 (24), p.2570-2578
  • Description: Objective To investigate the protective effect of dexmedetomidine on pulmonary edema in rats with hemorrhagic shock after exposure to a plateau environment. Methods A total of 280 SD male rats (10 weeks old, 200~220 g) were randomly divided into 4 groups: the plateau control (sham) group, the hemorrhagic shock after exposure to the plateau environment (HS) group, the lactated Ringer's resuscitation (LR) group, and the dexmedetomidine+lactated Ringer's resuscitation (DEX+LR) group.Using a low-pressure hypoxic chamber to simulate 5 000 m altitude, the rats have stayed the chamber for 48 h to accept pretreatment, injecting oleic acid treatment via the tail vein.After 0.5 h of induction of oleic acid, the rats were slowly drawn blood via the femoral artery (40% to 50% of the blood volume) to establish a model of hemorrhagic shock after exposure to the plateau environment.The effect of dexmedetomidine on pulmonary vascular permeability was observed by changes in lung water content, pulmonary microvascular permeabi
  • Publisher: Editorial Office of Journal of Army Medical University
  • Language: Chinese
  • Identifier: ISSN: 2097-0927
    DOI: 10.16016/j.2097-0927.202307057
  • Source: DOAJ Directory of Open Access Journals
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