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Clinical observation of intravitreal injection of Conbercept treating diabetic macularedema

Guo ji yan ke za zhi, 2017-06, Vol.17 (6), p.1105-1107 [Peer Reviewed Journal]

ISSN: 1672-5123 ;EISSN: 1672-5123 ;DOI: 10.3980/j.issn.1672-5123.2017.6.24

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  • Title:
    Clinical observation of intravitreal injection of Conbercept treating diabetic macularedema
  • Author: Li Jiang ; Jin Li ; Ai-Qin Nie
  • Subjects: central macular thickness ; conbercept ; diabetic macular edema
  • Is Part Of: Guo ji yan ke za zhi, 2017-06, Vol.17 (6), p.1105-1107
  • Description: AIM: To observe the clinical efficiency of intravitreal conbercept on diabetic macular edema(DME). METHODS: This was a single arm, open-babel prospective study. Twenty eyes from 20 patients(12 males and 8 females)with DME diagnosed by fundus fluorescein angiography(FFA)and optical coherence tomography(OCT)were enrolled. Before the injection, best-corrected visual acuity(BCVA)of early treatment of diabetic retinopathy study(ETDRS), non-contact tonometer, ophthalmoscope, fundus photography, fundus fluoresein angiograph(FFA), and OCT were examined. All affected eyes were treated with intravitreal conbercept 0.05mL(10mg/mL). Patients were followed up for 6 to 11mo, with a mean duration of 8.55±1.96mo. Post-treatment BCVA, CMT, leakage of macular edema and complications were compared with baseline using repeat analysis. RESULTS: The initial average visual acuity(ETDRS letters)were 43.35±17.45, range from 9 to 70. The initial average central macular thickness(CMT)was 576.30±167.92μm, range from 337 to 987μm. The mean BCVA showed significant improvement during 1, 3, 6mo post-treatment and the latest follow up, with a mean increase of 11.2±5.9, 13.8±7.9, 15.7±6.8 and 14.7±8.6, respectively(P<0.01). The changes of BCVA between before and at 1mo after treatment were different compared with the changes between before and at 6mo(P<0.01). During the latest follow up, the mean BCVA was obviously improved in 10 eyes(50%), improved in 7 eyes(35%), stable in 3 eyes(15%). Likewise, the mean CMT significantly decreased during the follow-up period with a mean CMT reduction of 183.8±159.5, 292.9±169.0, 271.4±167.2 and 286.4±166.9μm respectively(P<0.001). The CMT at 1mo were different with that 3, 6mo and final follow-up(P<0.01). During the latest follow up, macula lutea leakage disappeared in 6 eyes(30%), decreased in 12 eyes(60%)and increased in 2 eyes(10%). No adverse events such as secondary retinal detachment or endophthalmitis were found during the follow-up.CONCLUSION: Intravitreal conbercept significantly improve visual acuity and macular edema exudation.
  • Publisher: Press of International Journal of Ophthalmology (IJO PRESS)
  • Language: English
  • Identifier: ISSN: 1672-5123
    EISSN: 1672-5123
    DOI: 10.3980/j.issn.1672-5123.2017.6.24
  • Source: DOAJ Directory of Open Access Journals
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