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A [beta]-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice

ChemMedChem, 2014-04, Vol.9 (4), p.710-713 [Peer Reviewed Journal]

2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ;ISSN: 1860-7179 ;EISSN: 1860-7187 ;DOI: 10.1002/cmdc.201300325

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  • Title:
    A [beta]-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice
  • Author: Weinandy, Franziska ; Lorenz-Baath, Katrin ; Korotkov, Vadim S ; Bottcher, Thomas ; Sethi, Shneh ; Chakraborty, Trinad ; Sieber, Stephan A
  • Subjects: Medical research ; Staphylococcus aureus
  • Is Part Of: ChemMedChem, 2014-04, Vol.9 (4), p.710-713
  • Description: Skin infections caused by Staphylococcus aureus are a major clinical concern, especially if they are caused by multi-resistant strains. In these cases, a spread into deeper soft tissues or the bloodstream results in life-threatening conditions that are difficult to treat by conventional antibiotics. Previous in vitro experiments with a small [beta]-lactone-based molecule demonstrated that antibiotic-sensitive and -resistant S.aureus strains are effectively disarmed in their virulence and corresponding pathogenicity. In this work, in vivo mouse studies show that this methodology is effective for the treatment of skin abscesses in mice. A single dose of the [beta]-lactone significantly decreased abscess size even when applied 6h post-infection. Although the molecule requires pharmacological optimization (improved stability, for example), this study emphasizes the potential value of antivirulence therapies. [PUBLICATION ABSTRACT]
  • Publisher: Weinheim: Wiley Subscription Services, Inc
  • Language: English;German
  • Identifier: ISSN: 1860-7179
    EISSN: 1860-7187
    DOI: 10.1002/cmdc.201300325
  • Source: Alma/SFX Local Collection
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