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Subthalamic Deep Brain Stimulation Can Improve Gastric Emptying in Parkinson's Disease
Digestive diseases and sciences, 2022-05, Vol.57 (11), p.2733
[Peer Reviewed Journal]
COPYRIGHT 2022 Springer ;ISSN: 0163-2116 ;EISSN: 1573-2568
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Title:
Subthalamic Deep Brain Stimulation Can Improve Gastric Emptying in Parkinson's Disease
Author:
Arai, Eiji
;
Arai, Makoto
;
Maruoka, Daisuke
;
Matsumura, Tomoaki
;
Nakagawa, Tomoo
;
Katsuno, Tatsuro
;
Imazeki, Fumio
;
Yokosuka, Osamu
Subjects:
Dopa
;
Medical research
;
Medicine, Experimental
Is Part Of:
Digestive diseases and sciences, 2022-05, Vol.57 (11), p.2733
Description:
Introduction: It is established that anti-parkinsonian drugs and deep brain stimulation of the subthalamic nucleus (STN-DBS) improve motor dysfunction in advanced Parkinson's disease (PD). The present study was undertaken to investigate the effects of levodopa and STNDBS on gastric emptying (GE). Methods: A total of 16 patients with PD who underwent bilateral STN-DBS were enrolled. GE was assessed in patients with and without administration of 100-150 mg levodopa/decarboxylase-inhibitor (DCI) before surgery, and with and without STN-DBS at 3 months post-surgery. GE time was expressed as the peak time of 13CO2 excretion (Tmax) in the 13C-breath test. Results: The Tmax values for GE in patients without and with levodopa/DCI were 45.6 [+ or -] 22.7 and 42.5 [+ or -] 13.6 min, respectively, and the difference was not significant, which showed levodopa-resistance. The Tmax values without and with STN-DBS after surgery were 44.0 [+ or -] 17.5 and 30.0 [+ or -] 12.5 min, respectively, and the difference was statistically significant (p < 0.001). The difference between the Tmax values without levodopa/DCI before and without levodopa/ DCI and STN-DBS after surgery was not significant, although motor dysfunction improved and levodopa equivalent dose decreased after surgery. There was little association between changes in ghrelin levels ([DELTA]ghrelin) and changes in Tmax values ([DELTA]Tmax), and no association between changes in other characteristics and [DELTA]Tmax in the STN-DBS stimulation trial after surgery. Conclusion: STN-DBS can improve the dysfunctions of GE in patients with PD. This is the first report to show the effectiveness of STN-DBS on the levodopa-resistant gastrointestinal dysfunction as a non-motor symptom in PD.
Publisher:
Springer
Language:
English
Identifier:
ISSN: 0163-2116
EISSN: 1573-2568
Source:
AUTh Library subscriptions: ProQuest Central
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