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Evaluation of the potential of miR-21 as a diagnostic marker for oocyte maturity and embryo quality in women undergoing ICSI

Scientific reports, 2023-01, Vol.13 (1), p.1440-1440, Article 1440 [Peer Reviewed Journal]

2023. The Author(s). ;The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2023 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-023-28686-x ;PMID: 36697494

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  • Title:
    Evaluation of the potential of miR-21 as a diagnostic marker for oocyte maturity and embryo quality in women undergoing ICSI
  • Author: Jenabi, Maryam ; Khodarahmi, Parvin ; Tafvizi, Farzaneh ; Bostanabad, Saeed Zaker
  • Subjects: Female ; Follicular fluid ; Follicular Fluid - metabolism ; Humans ; Infertility ; Infertility, Female - diagnosis ; Infertility, Female - genetics ; Infertility, Female - therapy ; Male ; Maturation ; Maturity ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Oocytes ; Oocytes - metabolism ; Reproductive system ; Semen - metabolism ; Sperm Injections, Intracytoplasmic
  • Is Part Of: Scientific reports, 2023-01, Vol.13 (1), p.1440-1440, Article 1440
  • Description: MicroRNAs are small molecules that play a crucial role in regulating a woman's reproductive system. The present study evaluates the expression of miR-21 in the serum, follicular fluid (FF), and cumulus cells (CCs) and their association with oocyte maturity and embryo quality in women undergoing intracytoplasmic sperm injection. Women subjects were divided into the case (54 Patients with female factor infertility) and control groups (33 patients with male factor infertility). The level of miR-21 was measured using Real-Time PCR. The level of miR-21 was significantly lower in the CCs, FF, and serum in the case compared to the control group (p < 0.05). MiR-21 abundance was higher in FF and CCs samples than in serum. Furthermore, there was a significant increase in CCs to FF in the case group (p < 0.05). A significant decrease in oocyte count, MII oocytes, and percentage of mature oocytes were observed in the case group (p < 0.05). The expression of miR-21 in FF and CCs was positively related to oocyte maturation, but no correlation with embryo development was observed. This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21. Therefore, miR-21 could provide new helpful biomarkers of oocyte maturity.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/s41598-023-28686-x
    PMID: 36697494
  • Source: MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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