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Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

The New England journal of medicine, 2014-07, Vol.371 (2), p.119-129 [Peer Reviewed Journal]

Copyright © 2014 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;Copyright © 2014 Massachusetts Medical Society. 2014 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1313517 ;PMID: 25006718 ;CODEN: NEJMAG

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Title:
Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Author: Legro, Richard S ; Brzyski, Robert G ; Diamond, Michael P ; Coutifaris, Christos ; Schlaff, William D ; Casson, Peter ; Christman, Gregory M ; Huang, Hao ; Yan, Qingshang ; Alvero, Ruben ; Haisenleder, Daniel J ; Barnhart, Kurt T ; Bates, G. Wright ; Usadi, Rebecca ; Lucidi, Scott ; Baker, Valerie ; Trussell, J.C ; Krawetz, Stephen A ; Snyder, Peter ; Ohl, Dana ; Santoro, Nanette ; Eisenberg, Esther ; Zhang, Heping
Subjects: Abortion ; Adult ; Aromatase ; Biological and medical sciences ; Birth control ; Clomiphene ; Clomiphene - adverse effects ; Clomiphene - pharmacology ; Clomiphene - therapeutic use ; Comparative analysis ; Complications and side effects ; Congenital defects ; Dosage and administration ; Double-Blind Method ; Drug therapy ; Fallopian tube ; Fatigue ; Female ; Female genital diseases ; Fertility Agents, Female - adverse effects ; Fertility Agents, Female - pharmacology ; Fertility Agents, Female - therapeutic use ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility ; Infertility, Female - drug therapy ; Infertility, Female - etiology ; Kaplan-Meier Estimate ; Letrozole ; Live Birth ; Luteal Phase ; Male ; Medical sciences ; Nitriles - adverse effects ; Nitriles - pharmacology ; Nitriles - therapeutic use ; Non tumoral diseases ; Ovaries ; Ovulation ; Ovulation - drug effects ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - complications ; Pregnancy ; Quality of Life ; Reproductive health ; Stein-Leventhal syndrome ; Sterility. Assisted procreation ; Triazoles - adverse effects ; Triazoles - pharmacology ; Triazoles - therapeutic use ; Uterus ; Womens health
Is Part Of: The New England journal of medicine, 2014-07, Vol.371 (2), p.119-129
Description: This double-blind, multicenter, randomized trial showed that letrozole, as compared with clomiphene, was associated with higher live-birth and ovulation rates among infertile women with the polycystic ovary syndrome. The polycystic ovary syndrome, which is diagnosed on the basis of hyperandrogenism, oligo-ovulation with associated oligomenorrhea, and polycystic ovaries on ultrasonography, affects 5 to 10% of reproductive-age women and is the most common cause of anovulatory infertility. 1 Although the syndrome is a complex reproductive–metabolic disorder, the hypothalamic–pituitary axis has been the target of first-line ovulation-induction therapy. Clomiphene citrate, a selective estrogen-receptor modulator that antagonizes the negative feedback of estrogen at the hypothalamus with a consequent increase in ovarian stimulation by endogenous gonadotropin, has been used for this indication for decades. Clomiphene has drawbacks, including its overall poor efficacy (only a . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1313517
PMID: 25006718
CODEN: NEJMAG
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

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Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

Copyright © 2014 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;Copyright © 2014 Massachusetts Medical Society. 2014 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1313517 ;PMID: 25006718 ;CODEN: NEJMAG

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