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PROTEIN KINASE C MODULATORS
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Title:
PROTEIN KINASE C MODULATORS
Author:
YOUNG, Lindon
Subjects:
AGRICULTURE
;
ANIMAL HUSBANDRY
;
BEER
;
BIOCHEMISTRY
;
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
;
CHEMISTRY
;
COMPOSITIONS THEREOF
;
CULTURE MEDIA
;
ENZYMOLOGY
;
FISHING
;
FORESTRY
;
HUMAN NECESSITIES
;
HUNTING
;
HYGIENE
;
MEDICAL OR VETERINARY SCIENCE
;
METALLURGY
;
MICROBIOLOGY
;
MICROORGANISMS OR ENZYMES
;
MUTATION OR GENETIC ENGINEERING
;
ORGANIC CHEMISTRY
;
PEPTIDES
;
PEST REPELLANTS OR ATTRACTANTS
;
PLANT GROWTH REGULATORS
;
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
;
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
;
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
;
SPIRITS
;
TRAPPING
;
VINEGAR
;
WINE
Description:
The present invention relates to compounds effective for the modulation of members of the protein kinase C (PKC) enzymatic family, including but not limited to, protein kinase epsilon (PKCε) inhibitors, protein kinase beta II (PKCβII) inhibitors, protein kinase zeta (PKCζ) inhibitors, and protein kinase C delta (PKCδ) activators. The present disclosure also relates to the mitigation of reperfusion (R) injury following the restoration of blood flow to previously ischemic (I) tissue. The present disclosure additionally relates to conjugates of PKC modulator peptides and a transduction domain of Trans-Activator of Transcription (TAT), and lipidated adducts thereof. The present disclosure further relates to a method of improving the therapeutic efficacy and solubility of compounds and drugs via dual conjugation of TAT and lipid moieties such as, for example, myristoyl.
Creation Date:
2024
Language:
English;French;German
Source:
esp@cenet
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