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Incidence of anterior segment neovascularization during intravitreal treatment for macular edema secondary to central retinal vein occlusion

Arquivos brasileiros de oftalmologia, 2017-03, Vol.80 (2), p.97-103 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0004-2749 ;ISSN: 1678-2925 ;EISSN: 1678-2925 ;DOI: 10.5935/0004-2749.20170024 ;PMID: 28591282

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Title:
Incidence of anterior segment neovascularization during intravitreal treatment for macular edema secondary to central retinal vein occlusion
Author: Lucatto, Luiz Filipe Adami ; Magalhães-Junior, Octaviano ; Prazeres, Juliana M B ; Ferreira, Adriano M ; Oliveira, Ramon A ; Moraes, Nilva S ; Hirai, Flávio E ; Maia, Mauricio
Subjects: Adult ; Aged ; Aged, 80 and over ; Angiogenesis Inhibitors - administration & dosage ; Angiogenesis Inhibitors - adverse effects ; Anterior Eye Segment - blood supply ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - adverse effects ; Bevacizumab - administration & dosage ; Bevacizumab - adverse effects ; Double-Blind Method ; Female ; Follow-Up Studies ; Fovea Centralis - physiopathology ; Glaucoma, Neovascular - drug therapy ; Humans ; Incidence ; Intravitreal Injections ; Macular Edema - drug therapy ; Macular Edema - etiology ; Male ; Middle Aged ; Neovascularization, Pathologic - epidemiology ; Neovascularization, Pathologic - etiology ; OPHTHALMOLOGY ; Prospective Studies ; Retinal Artery Occlusion - complications ; Retinal Artery Occlusion - drug therapy ; Treatment Outcome ; Triamcinolone Acetonide - administration & dosage ; Triamcinolone Acetonide - adverse effects ; Visual Acuity
Is Part Of: Arquivos brasileiros de oftalmologia, 2017-03, Vol.80 (2), p.97-103
Description: To analyze the effects of injections of intravitreal triamcinolone acetonide (IVTA) and intravitreal bevacizumab (IVB) on the incidence rates of anterior segment neovascularization (ASN) and neovascular glaucoma (NVG) in patients with macular edema secondary to central retinal vein occlusion (CRVO). In this prospective, randomized, double-masked, sham-controlled study, 35 patients with macular edema following CRVO were randomized to intravitreal bevacizumab, intravitreal triamcinolone acetonide, or sham injections during the first 6 months of the study. The primary outcome was the incidence rate of ASN at month 6. The secondary outcomes were the mean changes from baseline in best-corrected visual acuity (BCVA) and central foveal thickness (CFT) on optical coherence tomography over time to month 12. ASN developed in 8 (22.86%) eyes, including 5 (62.50%) eyes in the sham group and 3 (37.50%) eyes in the IVTA group, during 12 months of fol low-up (p=0.009). BCVA differed significantly (p<0.05) among the groups only at month 1. CFT did not differ significantly (p<0.05) among the groups over 12 months. NVG required surgery and developed in one eye despite laser treatment. Early treatment with intravitreal antivascular endothelial growth factor therapy decreases the rates of ASN and NVG after CRVO.
Publisher: Brazil: Conselho Brasileiro de Oftalmologia
Language: English;Portuguese
Identifier: ISSN: 0004-2749
ISSN: 1678-2925
EISSN: 1678-2925
DOI: 10.5935/0004-2749.20170024
PMID: 28591282
Source: IngentaConnect Free/Open Access Journals
SciELO
GFMER Free Medical Journals
MEDLINE

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Incidence of anterior segment neovascularization during intravitreal treatment for macular edema secondary to central retinal vein occlusion

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0004-2749 ;ISSN: 1678-2925 ;EISSN: 1678-2925 ;DOI: 10.5935/0004-2749.20170024 ;PMID: 28591282

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