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Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications—a position report

Human reproduction (Oxford), 2010-04, Vol.25 (4), p.824-838 [Peer Reviewed Journal]

The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2010 ;2015 INIST-CNRS ;ISSN: 0268-1161 ;ISSN: 1460-2350 ;EISSN: 1460-2350 ;DOI: 10.1093/humrep/dep465 ;PMID: 20139429 ;CODEN: HUREEE

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Title:
Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications—a position report
Author: Barratt, Christopher L.R. ; Aitken, R. John ; Björndahl, Lars ; Carrell, Douglas T. ; de Boer, Peter ; Kvist, Ulrik ; Lewis, Sheena E.M. ; Perreault, Sally D. ; Perry, Melissa J. ; Ramos, Liliana ; Robaire, Bernard ; Ward, Steven ; Zini, Armand
Subjects: Animals ; Biological and medical sciences ; Chromatin - genetics ; DNA - genetics ; DNA Damage ; DNA Repair ; Environmental Pollutants - toxicity ; Epigenesis, Genetic ; Europe ; Female ; Fertilization - genetics ; Fertilization - physiology ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Male - diagnosis ; Infertility, Male - genetics ; Infertility, Male - therapy ; Male ; male infertilty ; Medical sciences ; Medicin och hälsovetenskap ; Pregnancy ; Societies, Medical ; sperm chromatin ; sperm DNA damage ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Zinc - metabolism
Is Part Of: Human reproduction (Oxford), 2010-04, Vol.25 (4), p.824-838
Description: This article reports the results of the most recent in a series of EHSRE workshops designed to synthesize the current state of the field in Andrology and provide recommendations for future work (for details see Appendix). Its focus is on methods for detecting sperm DNA damage and potential application of new knowledge about sperm chromatin organization, vulnerability and repair to improve the diagnosis and treatment of clinical infertility associated with that damage. Equally important is the use and reliability of these tests to identify the extent to which environmental contaminants or pharmaceutical agents may contribute to the incidence of sperm DNA damage and male fertility problems. A working group (for workshop details, see Appendix) under the auspices of ESHRE met in May 2009 to assess the current knowledgebase and suggest future basic and clinical research directions. This document presents a synthesis of the working group's understanding of the recent literature and collective discussions on the current state of knowledge of sperm chromatin structure and function during fertilization. It highlights the biological, assay and clinical uncertainties that require further research and ends with a series of 5 key recommendations.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 0268-1161
ISSN: 1460-2350
EISSN: 1460-2350
DOI: 10.1093/humrep/dep465
PMID: 20139429
CODEN: HUREEE
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
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Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications—a position report

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