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The genetic causes of male factor infertility: A review

Fertility and sterility, 2010, Vol.93 (1), p.1-12 [Peer Reviewed Journal]

American Society for Reproductive Medicine ;2010 American Society for Reproductive Medicine ;2015 INIST-CNRS ;Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2009.10.045 ;PMID: 20103481 ;CODEN: FESTAS

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Title:
The genetic causes of male factor infertility: A review
Author: O'Flynn O'Brien, Katherine L., B.A ; Varghese, Alex C., Ph.D ; Agarwal, Ashok, Ph.D
Subjects: AZF region ; Biological and medical sciences ; Birth control ; Chromosome Aberrations ; Chromosomes, Human, Y ; Epigenesis, Genetic ; epigenetics ; Fertility - genetics ; Genes, X-Linked ; Genetic Predisposition to Disease ; Genetic Testing ; genetics ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Male - diagnosis ; Infertility, Male - genetics ; Infertility, Male - physiopathology ; Infertility, Male - therapy ; Internal Medicine ; Male ; Male infertility ; Medical sciences ; Mutation ; Obstetrics and Gynecology ; Patient Selection ; Phenotype ; Polymorphism, Genetic ; Predictive Value of Tests ; Reproductive Techniques, Assisted ; Risk Factors ; Sterility. Assisted procreation ; Y chromosome
Is Part Of: Fertility and sterility, 2010, Vol.93 (1), p.1-12
Description: Objective To illustrate the necessity for an enhanced understanding of the genetic basis of male factor infertility, to present a comprehensive synopsis of these genetic elements, and to review techniques being utilized to produce new insights in fertility research. Background Male factor infertility is a complex disorder that affects a large sector of the population; however, many of its etiologies are unknown. By elucidating the underlying genetic basis of infertile phenotypes, it may be possible to discover the causes of infertility and determine effective treatments for patients. Method(s) The PubMed database was consulted for the most relevant papers published in the last 3 years pertaining to male factor infertility using the keywords “genetics” and “male infertility.” Result(s) Advances have been made in the characterization of the roles of specific genes, but further research is necessary before these results can be used as guidelines for diagnosing and treating male factor infertility. The accurate transmission of epigenetic information also has considerable influence on fertility in males and on the fertility of their offspring. Conclusion(s) Analysis of the genetic factors that impact male factor infertility will provide valuable insights into the creation of targeted treatments for patients and the determination of the causes of idiopathic infertility. Novel technologies that analyze the influence of genetics from a global perspective may lead to further developments in the understanding of the etiology of male factor infertility through the identification of specific infertile phenotype signatures.
Publisher: New York, NY: Elsevier Inc
Language: English
Identifier: ISSN: 0015-0282
EISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2009.10.045
PMID: 20103481
CODEN: FESTAS
Source: MEDLINE
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The genetic causes of male factor infertility: A review

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