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1-methyl-4-phenylpyridine (MPP +) induces oxidative stress in the rodent
Life sciences (1973), 1986-02, Vol.38 (8), p.743-749
[Peer Reviewed Journal]
1986 ;1986 INIST-CNRS ;ISSN: 0024-3205 ;EISSN: 1879-0631 ;DOI: 10.1016/0024-3205(86)90589-8 ;PMID: 3485234 ;CODEN: LIFSAK
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Title:
1-methyl-4-phenylpyridine (MPP +) induces oxidative stress in the rodent
Author:
Johannessen, Jan N.
;
Adams, James D.
;
Schuller, Hildegard M.
;
Bacon, John P.
;
Markey, Sanford P.
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
;
1-Methyl-4-phenylpyridinium
;
Animals
;
Anticonvulsants. Antiepileptics. Antiparkinson agents
;
Biological and medical sciences
;
Chemical and Drug Induced Liver Injury
;
Edema
;
Female
;
Glutathione - blood
;
Kidney Diseases - chemically induced
;
Kidney Diseases - pathology
;
Kinetics
;
Liver Diseases - pathology
;
Lung Diseases - chemically induced
;
Lung Diseases - pathology
;
Male
;
Medical sciences
;
Mice
;
Mice, Inbred C57BL
;
Neuropharmacology
;
Oxidation-Reduction
;
Pharmacology. Drug treatments
;
Pyridines - metabolism
;
Pyridines - toxicity
;
Pyridinium Compounds - metabolism
;
Pyridinium Compounds - toxicity
;
Rats
;
Rats, Inbred Strains
;
Selenium - deficiency
Is Part Of:
Life sciences (1973), 1986-02, Vol.38 (8), p.743-749
Description:
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) produces an irreversible parkinsonism in primates. Recent evidence suggests metabolism of MPTP to 1-methyl-4-phenylpyridine (MPP +) is required for toxicity. We have proposed that MPP + may play a central role in the toxicity of MPTP, but direct assessment of the effects of MPP + in brain is difficult. Therefore, we have sought to define the mechanism of peripheral MPP + toxicity in the rat and mouse. Systemically administered MPP + produced its major pathology in the lung and was typified by perivascular edema. An increase in plasma glutathione disulfide concentrations also resulted, suggesting that MPP + in analogy to paraquat produces oxidative stress. In addition, the lethality of MPP + in the mouse was increased by dietary selenium deficiency. These results define in both pathological and chemical terms the potent systemic toxicity of MPP + and suggest that MPP +, because of its high concentration in primate brain, has the potential to play an important role in the CNS toxicity of MPTP.
Publisher:
Amsterdam: Elsevier Inc
Language:
English
Identifier:
ISSN: 0024-3205
EISSN: 1879-0631
DOI: 10.1016/0024-3205(86)90589-8
PMID: 3485234
CODEN: LIFSAK
Source:
MEDLINE
Alma/SFX Local Collection
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