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1-year results of intravitreal aflibercept treatment for macular edema due to central retinal vein occlusion

Expert review of ophthalmology, 2013-06, Vol.8 (3), p.241-244 [Peer Reviewed Journal]

2013 Expert Reviews Ltd 2013 ;COPYRIGHT 2013 Expert Reviews Ltd. ;ISSN: 1746-9899 ;EISSN: 1746-9902 ;DOI: 10.1586/eop.13.22

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  • Title:
    1-year results of intravitreal aflibercept treatment for macular edema due to central retinal vein occlusion
  • Author: Stewart, Michael W
  • Subjects: aflibercept ; Care and treatment ; central retinal vein occlusion ; Dropsy ; Drug therapy ; Edema ; macular edema ; Patient outcomes ; Retinal diseases ; VEGF
  • Is Part Of: Expert review of ophthalmology, 2013-06, Vol.8 (3), p.241-244
  • Description: Evaluation of: Brown DM, Heier JS, Clark WL et al. Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the Phase III COPERNICUS study. Am. J. Ophthalmol. 155(3), 429-437 (2013).Macular edema due to central retinal vein occlusion is a significant cause of vision loss that had been untreatable until the recent introduction of intraocular triamcinolone injections, dexamethasone inserts and the newly developed VEGF-binding drugs, such as bevacizumab and ranibizumab. The VEGF-binding fusion molecule aflibercept recently completed the Phase III registration trials COPERNICUS (1-year results) and GALILEO (6-month results). Most patients (55.3%) receiving monthly injections of aflibercept in the COPERNICUS trial improved by at least 15 letters of vision at 52 weeks, and they outgained those in the original sham group by an average of 12.4 letters. Based on the results from these trials, aflibercept received US FDA approval for the treatment of central retinal vein occlusion-associated macular edema.
  • Publisher: London: Informa Healthcare
  • Language: English
  • Identifier: ISSN: 1746-9899
    EISSN: 1746-9902
    DOI: 10.1586/eop.13.22
  • Source: ProQuest Central
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