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1-Year Fixed-Regimen Bevacizumab Treatment in DME-Vascular Network Image Analysis in Optical Coherence Tomography Angiography Study

Journal of clinical medicine, 2022-04, Vol.11 (8), p.2125 [Peer Reviewed Journal]

2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 2077-0383 ;EISSN: 2077-0383 ;DOI: 10.3390/jcm11082125 ;PMID: 35456217

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  • Title:
    1-Year Fixed-Regimen Bevacizumab Treatment in DME-Vascular Network Image Analysis in Optical Coherence Tomography Angiography Study
  • Author: Hunt, Magdalena ; Wylęgała, Adam ; Wylęgała, Edward ; Teper, Sławomir
  • Subjects: AngioTool software ; Diabetes ; diabetic macular edema ; Diabetic retinopathy ; Edema ; Hypertension ; Kidney diseases ; Medical imaging ; Ophthalmology ; Outpatient care facilities ; Tomography ; Visual impairment
  • Is Part Of: Journal of clinical medicine, 2022-04, Vol.11 (8), p.2125
  • Description: To evaluate the effectiveness of intravitreal bevacizumab treatment in patients with diabetic macular edema (DME) by assessing retinal changes using AngioTool software (version 0.6a(02.18.14), National Cancer Institute, Bethesda, Maryland). A total of 27 eyes in patients with treatment-naïve DME were included in this prospective study. OCT-A images with a scan area of 6 × 6 mm were obtained. The DME patients with a central macular thickness (CMT) of ≥300 µm received nine bevacizumab injections within 12 months. The demographic, systemic, and ocular parameters, including the best-corrected visual acuity (BCVA) and CMT, were assessed. Explant area, vessels area, vessels percentage area, total number of junctions, total vessels length, average vessels length, the total number of endpoints, and mean lacunarity in the superficial capillary plexus (SCP) were calculated by using AngioTool software. Twenty-nine eyes of DME patients were subjected to the final analysis. Bevacizumab treatment reduced CMT from 401.84 ± 84.54 µm to 328.93 ± 87.17 µm and improved BCVA from 65.18 ± 8.21 at baseline to 72.63 ± 7.43 letters among participants of the study. The anti-VEGF therapy showed no statistically significant changes in parameters calculated by AngioTool software in the study group of patients. The fixed-regimen intravitreal bevacizumab therapy was effective in treating DME. AngioTool software is an additional tool that could be used to assess vascular networks. However, the use of OCTA is unlikely to alter DME treatment regimens significantly or to find significant predictors. Perhaps using wide-angle devices or software will give a complete picture of the disease and prove to be more helpful.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 2077-0383
    EISSN: 2077-0383
    DOI: 10.3390/jcm11082125
    PMID: 35456217
  • Source: Open Access: PubMed Central
    DOAJ Directory of Open Access Journals
    AUTh Library subscriptions: ProQuest Central
    ROAD: Directory of Open Access Scholarly Resources
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