skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review

BMC public health, 2014-01, Vol.14 (1), p.14-14, Article 14 [Peer Reviewed Journal]

COPYRIGHT 2014 BioMed Central Ltd. ;2014 Roberson et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright © 2014 Roberson et al.; licensee BioMed Central Ltd. 2014 Roberson et al.; licensee BioMed Central Ltd. ;ISSN: 1471-2458 ;EISSN: 1471-2458 ;DOI: 10.1186/1471-2458-14-14 ;PMID: 24400816

Full text available

Citations Cited by
  • Title:
    Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
  • Author: Roberson, Lara L ; Aneni, Ehimen C ; Maziak, Wasim ; Agatston, Arthur ; Feldman, Theodore ; Rouseff, Maribeth ; Tran, Thinh ; Blaha, Michael J ; Santos, Raul D ; Sposito, Andrei ; Al-Mallah, Mouaz H ; Blankstein, Ron ; Budoff, Matthew J ; Nasir, Khurram
  • Subjects: Analysis ; Body Mass Index ; Cardiovascular Diseases - etiology ; Carotid Intima-Media Thickness ; Cause of Death ; Diagnosis ; Female ; Genetic aspects ; Health aspects ; Humans ; Insulin Resistance ; Liver diseases ; Male ; Medical research ; Medicine, Experimental ; Metabolic Syndrome - complications ; Mortality ; Obesity ; Obesity - complications ; Obesity - mortality ; Phenotype ; Risk Factors ; Weight control ; Womens health
  • Is Part Of: BMC public health, 2014-01, Vol.14 (1), p.14-14, Article 14
  • Description: A subgroup has emerged within the obese that do not display the typical metabolic disorders associated with obesity and are hypothesized to have lower risk of complications. The purpose of this review was to analyze the literature which has examined the burden of cardiovascular disease (CVD) and all-cause mortality in the metabolically healthy obese (MHO) population. Pubmed, Cochrane Library, and Web of Science were searched from their inception until December 2012. Studies were included which clearly defined the MHO group (using either insulin sensitivity and/or components of metabolic syndrome AND obesity) and its association with either all cause mortality, CVD mortality, incident CVD, and/or subclinical CVD. A total of 20 studies were identified; 15 cohort and 5 cross-sectional. Eight studies used the NCEP Adult Treatment Panel III definition of metabolic syndrome to define "metabolically healthy", while another nine used insulin resistance. Seven studies assessed all-cause mortality, seven assessed CVD mortality, and nine assessed incident CVD. MHO was found to be significantly associated with all-cause mortality in two studies (30%), CVD mortality in one study (14%), and incident CVD in three studies (33%). Of the six studies which examined subclinical disease, four (67%) showed significantly higher mean common carotid artery intima media thickness (CCA-IMT), coronary artery calcium (CAC), or other subclinical CVD markers in the MHO as compared to their MHNW counterparts. MHO is an important, emerging phenotype with a CVD risk between healthy, normal weight and unhealthy, obese individuals. Successful work towards a universally accepted definition of MHO would improve (and simplify) future studies and aid inter-study comparisons. Usefulness of a definition inclusive of insulin sensitivity and stricter criteria for metabolic syndrome components as well as the potential addition of markers of fatty liver and inflammation should be explored. Clinicians should be hesitant to reassure patients that the metabolically benign phenotype is safe, as increased risk cardiovascular disease and death have been shown.
  • Publisher: England: BioMed Central Ltd
  • Language: English
  • Identifier: ISSN: 1471-2458
    EISSN: 1471-2458
    DOI: 10.1186/1471-2458-14-14
    PMID: 24400816
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    MEDLINE
    Springer OA刊
    ROAD: Directory of Open Access Scholarly Resources
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait