skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Cognitive deficits as an endophenotype for anorexia nervosa: An accepted fact or a need for re-examination?

The International journal of eating disorders, 2015-01, Vol.48 (1), p.15-25 [Peer Reviewed Journal]

2014 Wiley Periodicals, Inc. ;Copyright Wiley Subscription Services, Inc. Jan 2015 ;ISSN: 0276-3478 ;EISSN: 1098-108X ;DOI: 10.1002/eat.22332 ;PMID: 25046823 ;CODEN: INDIDJ

Full text available

Citations Cited by
  • Title:
    Cognitive deficits as an endophenotype for anorexia nervosa: An accepted fact or a need for re-examination?
  • Author: Talbot, Amy ; Hay, Phillipa ; Buckett, Geoffrey ; Touyz, Stephen
  • Subjects: Adolescent ; Adult ; Anorexia ; Anorexia Nervosa - genetics ; Anorexia Nervosa - psychology ; Body Mass Index ; central coherence ; cognition ; Cognition Disorders - genetics ; Cognitive therapy ; Depression - psychology ; Eating disorders ; endophenotype ; Endophenotypes ; Epidemiology ; Executive Function ; Female ; Genetics ; Humans ; information processing ; Male ; Neuropsychological Tests ; Patients ; Personality traits ; Quality of Life ; Questionnaires ; set shifting ; Surveys and Questionnaires ; Young Adult
  • Is Part Of: The International journal of eating disorders, 2015-01, Vol.48 (1), p.15-25
  • Description: ABSTRACT Objective To investigate whether impaired set shifting and weak central coherence represent state or trait characteristics and, therefore, candidate endophenotypes of anorexia nervosa (AN). Method Forty‐nine individuals with lifetime AN (24 acutely unwell, 10 weight recovered, and 15 fully recovered) and 43 healthy controls completed the Wisconsin Card Sorting Test (WCST), the Matching Familiar Figures Test, and the Rey Complex Figure Task measuring cognitive flexibility, local processing, and global processing, respectively. Participants also completed questionnaires assessing eating disorder, anxiety and depressive symptoms, obsessional traits, interpersonal functioning, and quality of life. Body mass index was calculated from height and weight measurements. Results Participants with lifetime AN demonstrated poorer set shifting ability than healthy controls as evidenced by a greater number of perseverative errors on the WCST. When participants were grouped according to illness status, only those in the two recovered groups demonstrated poorer set shifting ability than healthy controls while patients with acute AN performed comparably to all other groups. There were no significant differences between groups on measures of local and global processing. No relationship was found between specific clinical features of AN and cognitive performance. Discussion The results of this study are consistent with a global trend toward set shifting difficulties in patients with AN but do not support weak central coherence as a candidate endophenotype for AN. These findings have clinical implications in terms of treatment selection and planning, particularly in relation to the use of cognitive remediation therapy with patients with AN. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:15–25)
  • Publisher: United States: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 0276-3478
    EISSN: 1098-108X
    DOI: 10.1002/eat.22332
    PMID: 25046823
    CODEN: INDIDJ
  • Source: MEDLINE
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait